Stewart JB - Search Results

1

Cell lineage-specific mitochondrial resilience during mammalian organogenesis.

Burr SP, Klimm F, Glynos A, Prater M, Sendon P, Nash P, Powell CA, Simard ML, Bonekamp NA, Charl J, Diaz H, Bozhilova LV, Nie Y, Zhang H, Frison M, Falkenberg M, Jones N, Minczuk M, Stewart JB, Chinnery PF. Burr SP, et al. Among authors: stewart jb. Cell. 2023 Mar 16;186(6):1212-1229.e21. doi: 10.1016/j.cell.2023.01.034. Epub 2023 Feb 23. Cell. 2023. PMID: 36827974 Free article.

2

Variation in germline mtDNA heteroplasmy is determined prenatally but modified during subsequent transmission.

Freyer C, Cree LM, Mourier A, Stewart JB, Koolmeister C, Milenkovic D, Wai T, Floros VI, Hagström E, Chatzidaki EE, Wiesner RJ, Samuels DC, Larsson NG, Chinnery PF. Freyer C, et al. Among authors: stewart jb. Nat Genet. 2012 Nov;44(11):1282-5. doi: 10.1038/ng.2427. Epub 2012 Oct 7. Nat Genet. 2012. PMID: 23042113 Free PMC article.

3

In vivo mutagenesis reveals that OriL is essential for mitochondrial DNA replication.

Wanrooij S, Miralles Fusté J, Stewart JB, Wanrooij PH, Samuelsson T, Larsson NG, Gustafsson CM, Falkenberg M. Wanrooij S, et al. Among authors: stewart jb. EMBO Rep. 2012 Dec;13(12):1130-7. doi: 10.1038/embor.2012.161. Epub 2012 Oct 23. EMBO Rep. 2012. PMID: 23090476 Free PMC article.

4

MTERF1 binds mtDNA to prevent transcriptional interference at the light-strand promoter but is dispensable for rRNA gene transcription regulation.

Terzioglu M, Ruzzenente B, Harmel J, Mourier A, Jemt E, López MD, Kukat C, Stewart JB, Wibom R, Meharg C, Habermann B, Falkenberg M, Gustafsson CM, Park CB, Larsson NG. Terzioglu M, et al. Among authors: stewart jb. Cell Metab. 2013 Apr 2;17(4):618-26. doi: 10.1016/j.cmet.2013.03.006. Cell Metab. 2013. PMID: 23562081 Free article.

5

The challenges of mitochondrial replacement.

Chinnery PF, Craven L, Mitalipov S, Stewart JB, Herbert M, Turnbull DM. Chinnery PF, et al. Among authors: stewart jb. PLoS Genet. 2014 Apr 24;10(4):e1004315. doi: 10.1371/journal.pgen.1004315. eCollection 2014 Apr. PLoS Genet. 2014. PMID: 24762741 Free PMC article. No abstract available.

6

The exonuclease activity of DNA polymerase γ is required for ligation during mitochondrial DNA replication.

Macao B, Uhler JP, Siibak T, Zhu X, Shi Y, Sheng W, Olsson M, Stewart JB, Gustafsson CM, Falkenberg M. Macao B, et al. Among authors: stewart jb. Nat Commun. 2015 Jun 22;6:7303. doi: 10.1038/ncomms8303. Nat Commun. 2015. PMID: 26095671 Free PMC article.

7

The dynamics of mitochondrial DNA heteroplasmy: implications for human health and disease.

Stewart JB, Chinnery PF. Stewart JB, et al. Nat Rev Genet. 2015 Sep;16(9):530-42. doi: 10.1038/nrg3966. Nat Rev Genet. 2015. PMID: 26281784 Review.

8

Complementation between polymerase- and exonuclease-deficient mitochondrial DNA polymerase mutants in genomically engineered flies.

Bratic A, Kauppila TE, Macao B, Grönke S, Siibak T, Stewart JB, Baggio F, Dols J, Partridge L, Falkenberg M, Wredenberg A, Larsson NG. Bratic A, et al. Among authors: stewart jb. Nat Commun. 2015 Nov 10;6:8808. doi: 10.1038/ncomms9808. Nat Commun. 2015. PMID: 26554610 Free PMC article.

9

A Phenotype-Driven Approach to Generate Mouse Models with Pathogenic mtDNA Mutations Causing Mitochondrial Disease.

Kauppila JHK, Baines HL, Bratic A, Simard ML, Freyer C, Mourier A, Stamp C, Filograna R, Larsson NG, Greaves LC, Stewart JB. Kauppila JHK, et al. Among authors: stewart jb. Cell Rep. 2016 Sep 13;16(11):2980-2990. doi: 10.1016/j.celrep.2016.08.037. Cell Rep. 2016. PMID: 27626666 Free PMC article.

10

Increased Total mtDNA Copy Number Cures Male Infertility Despite Unaltered mtDNA Mutation Load.

Jiang M, Kauppila TES, Motori E, Li X, Atanassov I, Folz-Donahue K, Bonekamp NA, Albarran-Gutierrez S, Stewart JB, Larsson NG. Jiang M, et al. Among authors: stewart jb. Cell Metab. 2017 Aug 1;26(2):429-436.e4. doi: 10.1016/j.cmet.2017.07.003. Cell Metab. 2017. PMID: 28768180 Free article.

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