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Identifying multiscale translational safety biomarkers using a network-based systems approach.
Callegaro G, Schimming JP, Piñero González J, Kunnen SJ, Wijaya L, Trairatphisan P, van den Berk L, Beetsma K, Furlong LI, Sutherland JJ, Mollon J, Stevens JL, van de Water B. Callegaro G, et al. Among authors: wijaya l. iScience. 2023 Jan 31;26(3):106094. doi: 10.1016/j.isci.2023.106094. eCollection 2023 Mar 17. iScience. 2023. PMID: 36895646 Free PMC article.
Integration of temporal single cell cellular stress response activity with logic-ODE modeling reveals activation of ATF4-CHOP axis as a critical predictor of drug-induced liver injury.
Wijaya LS, Trairatphisan P, Gabor A, Niemeijer M, Keet J, Alcalà Morera A, Snijders KE, Wink S, Yang H, Schildknecht S, Stevens JL, Bouwman P, Kamp H, Hengstler J, Beltman J, Leist M, Le Dévédec S, Saez-Rodriguez J, van de Water B. Wijaya LS, et al. Biochem Pharmacol. 2021 Aug;190:114591. doi: 10.1016/j.bcp.2021.114591. Epub 2021 May 4. Biochem Pharmacol. 2021. PMID: 33957093 Free article.
Model-based translation of DNA damage signaling dynamics across cell types.
Heldring MM, Wijaya LS, Niemeijer M, Yang H, Lakhal T, Le Dévédec SE, van de Water B, Beltman JB. Heldring MM, et al. PLoS Comput Biol. 2022 Jul 8;18(7):e1010264. doi: 10.1371/journal.pcbi.1010264. eCollection 2022 Jul. PLoS Comput Biol. 2022. PMID: 35802572 Free PMC article.
Protectiveness of NAM-based hazard assessment - which testing scope is required?
Zobl W, Bitsch A, Blum J, Boei JJWA, Capinha L, Carta G, Castell J, Davoli E, Drake C, Fisher CP, Heldring MM, Islam B, Jennings P, Leist M, Pellegrino-Coppola D, Schimming JP, Snijders KE, Tolosa L, van de Water B, van Vugt-Lussenburg BMA, Walker P, Wehr MM, Wijaya LS, Escher SE. Zobl W, et al. Among authors: wijaya ls. ALTEX. 2024;41(2):302-319. doi: 10.14573/altex.2309081. Epub 2023 Dec 4. ALTEX. 2024. PMID: 38048429 Free article.
161 results