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The confluence of machine learning and multiscale simulations.
Bhatia H, Aydin F, Carpenter TS, Lightstone FC, Bremer PT, Ingólfsson HI, Nissley DV, Streitz FH. Bhatia H, et al. Among authors: lightstone fc. Curr Opin Struct Biol. 2023 Jun;80:102569. doi: 10.1016/j.sbi.2023.102569. Epub 2023 Mar 24. Curr Opin Struct Biol. 2023. PMID: 36966691 Review.
Pharmacokinetic characterization in xenografted mice of a series of first-generation mimics for HLA-DR antibody, Lym-1, as carrier molecules to image and treat lymphoma.
DeNardo GL, Natarajan A, Hok S, Perkins J, Cosman M, DeNardo SJ, Lightstone FC, Mirick GR, Miers LA, Balhorn RL. DeNardo GL, et al. Among authors: lightstone fc. J Nucl Med. 2007 Aug;48(8):1338-47. doi: 10.2967/jnumed.107.041095. Epub 2007 Jul 13. J Nucl Med. 2007. PMID: 17631545 Free article.
The use of one-bead one-compound combinatorial library technology to discover high-affinity αvβ3 integrin and cancer targeting arginine-glycine-aspartic acid ligands with a built-in handle.
Xiao W, Wang Y, Lau EY, Luo J, Yao N, Shi C, Meza L, Tseng H, Maeda Y, Kumaresan P, Liu R, Lightstone FC, Takada Y, Lam KS. Xiao W, et al. Among authors: lightstone fc. Mol Cancer Ther. 2010 Oct;9(10):2714-23. doi: 10.1158/1535-7163.MCT-10-0308. Epub 2010 Sep 21. Mol Cancer Ther. 2010. PMID: 20858725 Free PMC article.
Pyrrolopyrimidine inhibitors of DNA gyrase B (GyrB) and topoisomerase IV (ParE), Part II: development of inhibitors with broad spectrum, Gram-negative antibacterial activity.
Trzoss M, Bensen DC, Li X, Chen Z, Lam T, Zhang J, Creighton CJ, Cunningham ML, Kwan B, Stidham M, Nelson K, Brown-Driver V, Castellano A, Shaw KJ, Lightstone FC, Wong SE, Nguyen TB, Finn J, Tari LW. Trzoss M, et al. Among authors: lightstone fc. Bioorg Med Chem Lett. 2013 Mar 1;23(5):1537-43. doi: 10.1016/j.bmcl.2012.11.073. Epub 2012 Dec 8. Bioorg Med Chem Lett. 2013. PMID: 23294697
89 results