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Alkyl-guanidine Compounds as Potent Broad-Spectrum Antibacterial Agents: Chemical Library Extension and Biological Characterization.
Pasero C, D'Agostino I, De Luca F, Zamperini C, Deodato D, Truglio GI, Sannio F, Del Prete R, Ferraro T, Visaggio D, Mancini A, Guglielmi MB, Visca P, Docquier JD, Botta M. Pasero C, et al. Among authors: truglio gi. J Med Chem. 2018 Oct 25;61(20):9162-9176. doi: 10.1021/acs.jmedchem.8b00619. Epub 2018 Oct 11. J Med Chem. 2018. PMID: 30265809
In vitro characterization, ADME analysis, and histological and toxicological evaluation of BM1, a macrocyclic amidinourea active against azole-resistant Candida strains.
Orofino F, Truglio GI, Fiorucci D, D'Agostino I, Borgini M, Poggialini F, Zamperini C, Dreassi E, Maccari L, Torelli R, Martini C, Bernabei M, Meis JF, Khandelwal NK, Prasad R, Sanguinetti M, Bugli F, Botta M. Orofino F, et al. Among authors: truglio gi. Int J Antimicrob Agents. 2020 Mar;55(3):105865. doi: 10.1016/j.ijantimicag.2019.105865. Epub 2019 Dec 20. Int J Antimicrob Agents. 2020. PMID: 31866465
Focused library of phenyl-fused macrocyclic amidinoureas as antifungal agents.
Balestri LJI, D'Agostino I, Rango E, Vagaggini C, Marchitiello R, Mariotti M, Casian A, Deodato D, Truglio GI, Orofino F, Sanguinetti M, Bugli F, Botta L, Dreassi E. Balestri LJI, et al. Among authors: truglio gi. Mol Divers. 2022 Dec;26(6):3399-3409. doi: 10.1007/s11030-022-10388-7. Epub 2022 Feb 10. Mol Divers. 2022. PMID: 35143033 Free PMC article.
CanB, a Druggable Cellular Target in Mycobacterium tuberculosis.
Degiacomi G, Gianibbi B, Recchia D, Stelitano G, Truglio GI, Marra P, Stamilla A, Makarov V, Chiarelli LR, Manetti F, Pasca MR. Degiacomi G, et al. Among authors: truglio gi. ACS Omega. 2023 Jul 3;8(28):25209-25220. doi: 10.1021/acsomega.3c02311. eCollection 2023 Jul 18. ACS Omega. 2023. PMID: 37483251 Free PMC article.