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Protein homeostasis in aging and cancer.
Chen XQ, Shen T, Fang SJ, Sun XM, Li GY, Li YF. Chen XQ, et al. Front Cell Dev Biol. 2023 Feb 16;11:1143532. doi: 10.3389/fcell.2023.1143532. eCollection 2023. Front Cell Dev Biol. 2023. PMID: 36875752 Free PMC article. Review.
Cholesterol reduction by immunization with a PCSK9 mimic.
Zhang B, Chuang GY, Biju A, Biner D, Cheng J, Wang Y, Bao S, Chao CW, Lei H, Liu T, Nazzari AF, Yang Y, Zhou T, Chen SJ, Chen X, Kong WP, Ou L, Parchment DK, Sarfo EK, SiMa H, Todd JP, Wang S, Woodward RA, Cheng C, Rawi R, Mascola JR, Kwong PD. Zhang B, et al. Among authors: chen x. Cell Rep. 2024 May 30;43(6):114285. doi: 10.1016/j.celrep.2024.114285. Online ahead of print. Cell Rep. 2024. PMID: 38819987
Oral estrogen receptor PROTAC® vepdegestrant (ARV-471) is highly efficacious as monotherapy and in combination with CDK4/6 or PI3K/mTOR pathway inhibitors in preclinical ER+ breast cancer models.
Gough SM, Flanagan JJ, Teh J, Andreoli M, Rousseau E, Pannone M, Bookbinder M, Willard R, Davenport K, Bortolon E, Cadelina G, Gordon D, Pizzano J, Macaluso J, Soto L, Corradi J, Digianantonio K, Drulyte I, Morgan A, Quinn C, Békés M, Ferraro C, Chen X, Wang G, Dong H, Wang J, Langley DR, Houston J, Gedrich R, Taylor IC. Gough SM, et al. Among authors: chen x. Clin Cancer Res. 2024 May 31. doi: 10.1158/1078-0432.CCR-23-3465. Online ahead of print. Clin Cancer Res. 2024. PMID: 38819400
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