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Dynamic BH3 profiling identifies pro-apoptotic drug combinations for the treatment of malignant pleural mesothelioma.
Nat Commun. 2023 May 20;14(1):2897. doi: 10.1038/s41467-023-38552-z.
Nat Commun. 2023.
PMID: 37210412
Free PMC article.
To Prime, or Not to Prime: That Is the Question.
Potter DS, Letai A.
Potter DS, et al.
Cold Spring Harb Symp Quant Biol. 2016;81:131-140. doi: 10.1101/sqb.2016.81.030841. Epub 2016 Nov 3.
Cold Spring Harb Symp Quant Biol. 2016.
PMID: 27811212
Review.
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Dynamic BH3 profiling identifies active BH3 mimetic combinations in non-small cell lung cancer.
Potter DS, Du R, Bhola P, Bueno R, Letai A.
Potter DS, et al.
Cell Death Dis. 2021 Jul 27;12(8):741. doi: 10.1038/s41419-021-04029-4.
Cell Death Dis. 2021.
PMID: 34315868
Free PMC article.
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Metabolic perturbations sensitize triple-negative breast cancers to apoptosis induced by BH3 mimetics.
Daniels VW, Zoeller JJ, van Gastel N, McQueeney KE, Parvin S, Potter DS, Fell GG, Ferreira VG, Yilma B, Gupta R, Spetz J, Bhola PD, Endress JE, Harris IS, Carrilho E, Sarosiek KA, Scadden DT, Brugge JS, Letai A.
Daniels VW, et al. Among authors: potter ds.
Sci Signal. 2021 Jun 8;14(686):eabc7405. doi: 10.1126/scisignal.abc7405.
Sci Signal. 2021.
PMID: 34103421
Free PMC article.
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ER Stress Signaling Promotes the Survival of Cancer "Persister Cells" Tolerant to EGFR Tyrosine Kinase Inhibitors.
Terai H, Kitajima S, Potter DS, Matsui Y, Quiceno LG, Chen T, Kim TJ, Rusan M, Thai TC, Piccioni F, Donovan KA, Kwiatkowski N, Hinohara K, Wei G, Gray NS, Fischer ES, Wong KK, Shimamura T, Letai A, Hammerman PS, Barbie DA.
Terai H, et al. Among authors: potter ds.
Cancer Res. 2018 Feb 15;78(4):1044-1057. doi: 10.1158/0008-5472.CAN-17-1904. Epub 2017 Dec 19.
Cancer Res. 2018.
PMID: 29259014
Free PMC article.
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Adding venetoclax to fludarabine/busulfan RIC transplant for high-risk MDS and AML is feasible, safe, and active.
Garcia JS, Kim HT, Murdock HM, Cutler CS, Brock J, Gooptu M, Ho VT, Koreth J, Nikiforow S, Romee R, Shapiro R, Loschi F, Ryan J, Fell G, Karp HQ, Lucas F, Kim AS, Potter D, Mashaka T, Stone RM, DeAngelo DJ, Letai A, Lindsley RC, Soiffer RJ, Antin JH.
Garcia JS, et al.
Blood Adv. 2021 Dec 28;5(24):5536-5545. doi: 10.1182/bloodadvances.2021005566.
Blood Adv. 2021.
PMID: 34614506
Free PMC article.
Clinical Trial.
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BMX acts downstream of PI3K to promote colorectal cancer cell survival and pathway inhibition sensitizes to the BH3 mimetic ABT-737.
Potter DS, Kelly P, Denneny O, Juvin V, Stephens LR, Dive C, Morrow CJ.
Potter DS, et al.
Neoplasia. 2014 Feb;16(2):147-57. doi: 10.1593/neo.131376.
Neoplasia. 2014.
PMID: 24709422
Free PMC article.
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Inhibition of PI3K/BMX Cell Survival Pathway Sensitizes to BH3 Mimetics in SCLC.
Potter DS, Galvin M, Brown S, Lallo A, Hodgkinson CL, Blackhall F, Morrow CJ, Dive C.
Potter DS, et al.
Mol Cancer Ther. 2016 Jun;15(6):1248-60. doi: 10.1158/1535-7163.MCT-15-0885. Epub 2016 Mar 29.
Mol Cancer Ther. 2016.
PMID: 27197306
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