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Combining the antianginal drug perhexiline with chemotherapy induces complete pancreatic cancer regression in vivo.
Reyes-Castellanos G, Abdel Hadi N, Gallardo-Arriaga S, Masoud R, Garcia J, Lac S, El Kaoutari A, Gicquel T, Planque M, Fendt SM, Linares LK, Gayet O, Guillaumond F, Dusetti N, Iovanna J, Carrier A. Reyes-Castellanos G, et al. Among authors: linares lk. iScience. 2023 May 19;26(6):106899. doi: 10.1016/j.isci.2023.106899. eCollection 2023 Jun 16. iScience. 2023. PMID: 37305702 Free PMC article.
RIP140 inhibits glycolysis-dependent proliferation of breast cancer cells by regulating GLUT3 expression through transcriptional crosstalk between hypoxia induced factor and p53.
Jacquier V, Gitenay D, Fritsch S, Bonnet S, Győrffy B, Jalaguier S, Linares LK, Cavaillès V, Teyssier C. Jacquier V, et al. Among authors: linares lk. Cell Mol Life Sci. 2022 May 3;79(5):270. doi: 10.1007/s00018-022-04277-3. Cell Mol Life Sci. 2022. PMID: 35501580 Free PMC article.
The multifunctional protein E4F1 links P53 to lipid metabolism in adipocytes.
Lacroix M, Linares LK, Rueda-Rincon N, Bloch K, Di Michele M, De Blasio C, Fau C, Gayte L, Blanchet E, Mairal A, Derua R, Cardona F, Beuzelin D, Annicotte JS, Pirot N, Torro A, Tinahones FJ, Bernex F, Bertrand-Michel J, Langin D, Fajas L, Swinnen JV, Le Cam L. Lacroix M, et al. Among authors: linares lk. Nat Commun. 2021 Dec 2;12(1):7037. doi: 10.1038/s41467-021-27307-3. Nat Commun. 2021. PMID: 34857760 Free PMC article.
Mitochondrial metabolism supports resistance to IDH mutant inhibitors in acute myeloid leukemia.
Stuani L, Sabatier M, Saland E, Cognet G, Poupin N, Bosc C, Castelli FA, Gales L, Turtoi E, Montersino C, Farge T, Boet E, Broin N, Larrue C, Baran N, Cissé MY, Conti M, Loric S, Kaoma T, Hucteau A, Zavoriti A, Sahal A, Mouchel PL, Gotanègre M, Cassan C, Fernando L, Wang F, Hosseini M, Chu-Van E, Le Cam L, Carroll M, Selak MA, Vey N, Castellano R, Fenaille F, Turtoi A, Cazals G, Bories P, Gibon Y, Nicolay B, Ronseaux S, Marszalek JR, Takahashi K, DiNardo CD, Konopleva M, Pancaldi V, Collette Y, Bellvert F, Jourdan F, Linares LK, Récher C, Portais JC, Sarry JE. Stuani L, et al. Among authors: linares lk. J Exp Med. 2021 May 3;218(5):e20200924. doi: 10.1084/jem.20200924. J Exp Med. 2021. PMID: 33760042 Free PMC article.
The p53 Pathway and Metabolism: The Tree That Hides the Forest.
Lahalle A, Lacroix M, De Blasio C, Cissé MY, Linares LK, Le Cam L. Lahalle A, et al. Among authors: linares lk. Cancers (Basel). 2021 Jan 4;13(1):133. doi: 10.3390/cancers13010133. Cancers (Basel). 2021. PMID: 33406607 Free PMC article. Review.
Targeting MDM2-dependent serine metabolism as a therapeutic strategy for liposarcoma.
Cissé MY, Pyrdziak S, Firmin N, Gayte L, Heuillet M, Bellvert F, Fuentes M, Delpech H, Riscal R, Arena G, Chibon F, Le Gellec S, Maran-Gonzalez A, Chateau MC, Theillet C, Carrere S, Portais JC, Le Cam L, Linares LK. Cissé MY, et al. Among authors: linares lk. Sci Transl Med. 2020 Jun 10;12(547):eaay2163. doi: 10.1126/scitranslmed.aay2163. Sci Transl Med. 2020. PMID: 32522803
TAG-RNAi overcomes off-target effects in cancer models.
Champagne J, Linares LK, Maurel B, Zampieri A, Moreno M, Fuentes I, Dubois E, Severac D, Decorsière A, Bienvenu F. Champagne J, et al. Among authors: linares lk. Oncogene. 2020 Jan;39(4):935-945. doi: 10.1038/s41388-019-1020-2. Epub 2019 Sep 26. Oncogene. 2020. PMID: 31558799
37 results