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Chemokine binding to PSGL-1 is controlled by O-glycosylation and tyrosine sulfation.
Goth CK, Mehta AY, McQuillan AM, Baker KJ, Hanes MS, Park SS, Stavenhagen K, Hjortø GM, Heimburg-Molinaro J, Chaikof EL, Rosenkilde MM, Cummings RD. Goth CK, et al. Cell Chem Biol. 2023 Aug 17;30(8):893-905.e7. doi: 10.1016/j.chembiol.2023.06.013. Epub 2023 Jul 17. Cell Chem Biol. 2023. PMID: 37463583
Parallel Glyco-SPOT Synthesis of Glycopeptide Libraries.
Mehta AY, Veeraiah RKH, Dutta S, Goth CK, Hanes MS, Gao C, Stavenhagen K, Kardish R, Matsumoto Y, Heimburg-Molinaro J, Boyce M, Pohl NLB, Cummings RD. Mehta AY, et al. Among authors: goth ck. Cell Chem Biol. 2020 Sep 17;27(9):1207-1219.e9. doi: 10.1016/j.chembiol.2020.06.007. Epub 2020 Jun 30. Cell Chem Biol. 2020. PMID: 32610041 Free PMC article.
Development of smart anti-glycan reagents using immunized lampreys.
McKitrick TR, Goth CK, Rosenberg CS, Nakahara H, Heimburg-Molinaro J, McQuillan AM, Falco R, Rivers NJ, Herrin BR, Cooper MD, Cummings RD. McKitrick TR, et al. Among authors: goth ck. Commun Biol. 2020 Feb 28;3(1):91. doi: 10.1038/s42003-020-0819-2. Commun Biol. 2020. PMID: 32111965 Free PMC article.
"Glyco-sulfo barcodes" regulate chemokine receptor function.
Verhallen L, Lackman JJ, Wendt R, Gustavsson M, Yang Z, Narimatsu Y, Sørensen DM, Lafferty KM, Gouwy M, Marques PE, Hjortø GM, Rosenkilde MM, Proost P, Goth CK. Verhallen L, et al. Among authors: goth ck. Cell Mol Life Sci. 2023 Feb 2;80(2):55. doi: 10.1007/s00018-023-04697-9. Cell Mol Life Sci. 2023. PMID: 36729338 Free PMC article.
The C-terminal peptide of CCL21 drastically augments CCL21 activity through the dendritic cell lymph node homing receptor CCR7 by interaction with the receptor N-terminus.
Jørgensen AS, Brandum EP, Mikkelsen JM, Orfin KA, Boilesen DR, Egerod KL, Moussouras NA, Vilhardt F, Kalinski P, Basse P, Chen YH, Yang Z, Dwinell MB, Volkman BF, Veldkamp CT, Holst PJ, Lahl K, Goth CK, Rosenkilde MM, Hjortø GM. Jørgensen AS, et al. Among authors: goth ck. Cell Mol Life Sci. 2021 Nov;78(21-22):6963-6978. doi: 10.1007/s00018-021-03930-7. Epub 2021 Sep 29. Cell Mol Life Sci. 2021. PMID: 34586443 Free PMC article.
An atlas of O-linked glycosylation on peptide hormones reveals diverse biological roles.
Madsen TD, Hansen LH, Hintze J, Ye Z, Jebari S, Andersen DB, Joshi HJ, Ju T, Goetze JP, Martin C, Rosenkilde MM, Holst JJ, Kuhre RE, Goth CK, Vakhrushev SY, Schjoldager KT. Madsen TD, et al. Among authors: goth ck. Nat Commun. 2020 Aug 20;11(1):4033. doi: 10.1038/s41467-020-17473-1. Nat Commun. 2020. PMID: 32820167 Free PMC article.
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