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Chemokine binding to PSGL-1 is controlled by O-glycosylation and tyrosine sulfation.
Goth CK, Mehta AY, McQuillan AM, Baker KJ, Hanes MS, Park SS, Stavenhagen K, Hjortø GM, Heimburg-Molinaro J, Chaikof EL, Rosenkilde MM, Cummings RD. Goth CK, et al. Among authors: hjorto gm. Cell Chem Biol. 2023 Aug 17;30(8):893-905.e7. doi: 10.1016/j.chembiol.2023.06.013. Epub 2023 Jul 17. Cell Chem Biol. 2023. PMID: 37463583
"Glyco-sulfo barcodes" regulate chemokine receptor function.
Verhallen L, Lackman JJ, Wendt R, Gustavsson M, Yang Z, Narimatsu Y, Sørensen DM, Lafferty KM, Gouwy M, Marques PE, Hjortø GM, Rosenkilde MM, Proost P, Goth CK. Verhallen L, et al. Among authors: hjorto gm. Cell Mol Life Sci. 2023 Feb 2;80(2):55. doi: 10.1007/s00018-023-04697-9. Cell Mol Life Sci. 2023. PMID: 36729338 Free PMC article.
Probing Biased Signaling in Chemokine Receptors.
Amarandi RM, Hjortø GM, Rosenkilde MM, Karlshøj S. Amarandi RM, et al. Among authors: hjorto gm. Methods Enzymol. 2016;570:155-86. doi: 10.1016/bs.mie.2015.09.001. Epub 2015 Nov 14. Methods Enzymol. 2016. PMID: 26921946 Review.
The C-terminal peptide of CCL21 drastically augments CCL21 activity through the dendritic cell lymph node homing receptor CCR7 by interaction with the receptor N-terminus.
Jørgensen AS, Brandum EP, Mikkelsen JM, Orfin KA, Boilesen DR, Egerod KL, Moussouras NA, Vilhardt F, Kalinski P, Basse P, Chen YH, Yang Z, Dwinell MB, Volkman BF, Veldkamp CT, Holst PJ, Lahl K, Goth CK, Rosenkilde MM, Hjortø GM. Jørgensen AS, et al. Among authors: hjorto gm. Cell Mol Life Sci. 2021 Nov;78(21-22):6963-6978. doi: 10.1007/s00018-021-03930-7. Epub 2021 Sep 29. Cell Mol Life Sci. 2021. PMID: 34586443 Free PMC article.
34 results