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Ribosome subunit attrition and activation of the p53-MDM4 axis dominate the response of MLL-rearranged cancer cells to WDR5 WIN site inhibition.
bioRxiv [Preprint]. 2024 Jan 10:2023.07.26.550648. doi: 10.1101/2023.07.26.550648.
bioRxiv. 2024.
PMID: 37546802
Free PMC article.
Updated.
Preprint.
WIN site inhibition disrupts a subset of WDR5 function.
Siladi AJ, Wang J, Florian AC, Thomas LR, Creighton JH, Matlock BK, Flaherty DK, Lorey SL, Howard GC, Fesik SW, Weissmiller AM, Liu Q, Tansey WP.
Siladi AJ, et al. Among authors: florian ac.
Sci Rep. 2022 Feb 3;12(1):1848. doi: 10.1038/s41598-022-05947-9.
Sci Rep. 2022.
PMID: 35115608
Free PMC article.
Item in Clipboard
Synergistic action of WDR5 and HDM2 inhibitors in SMARCB1-deficient cancer cells.
Florian AC, Woodley CM, Wang J, Grieb BC, Slota MJ, Guerrazzi K, Hsu CY, Matlock BK, Flaherty DK, Lorey SL, Fesik SW, Howard GC, Liu Q, Weissmiller AM, Tansey WP.
Florian AC, et al.
NAR Cancer. 2022 Mar 3;4(1):zcac007. doi: 10.1093/narcan/zcac007. eCollection 2022 Mar.
NAR Cancer. 2022.
PMID: 35252869
Free PMC article.
Item in Clipboard
The SWI/SNF ATPase BRG1 facilitates multiple pro-tumorigenic gene expression programs in SMARCB1-deficient cancer cells.
Moe KC, Maxwell JN, Wang J, Jones CA, Csaki GT, Florian AC, Romer AS, Bryant DL, Farone AL, Liu Q, Tansey WP, Weissmiller AM.
Moe KC, et al. Among authors: florian ac.
Oncogenesis. 2022 Jun 1;11(1):30. doi: 10.1038/s41389-022-00406-6.
Oncogenesis. 2022.
PMID: 35650187
Free PMC article.
Item in Clipboard
Mitotic gene regulation by the N-MYC-WDR5-PDPK1 nexus.
Streeter SA, Williams AG, Evans JR, Wang J, Guarnaccia AD, Florian AC, Al-Tobasei R, Liu Q, Tansey WP, Weissmiller AM.
Streeter SA, et al. Among authors: florian ac.
BMC Genomics. 2024 Apr 11;25(1):360. doi: 10.1186/s12864-024-10282-6.
BMC Genomics. 2024.
PMID: 38605297
Free PMC article.
Item in Clipboard
Ribosome subunit attrition and activation of the p53-MDM4 axis dominate the response of MLL-rearranged cancer cells to WDR5 WIN site inhibition.
Howard GC, Wang J, Rose KL, Jones C, Patel P, Tsui T, Florian AC, Vlach L, Lorey SL, Grieb BC, Smith BN, Slota MJ, Reynolds EM, Goswami S, Savona MR, Mason FM, Lee T, Fesik S, Liu Q, Tansey WP.
Howard GC, et al. Among authors: florian ac.
Elife. 2024 Apr 29;12:RP90683. doi: 10.7554/eLife.90683.
Elife. 2024.
PMID: 38682900
Free PMC article.
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