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VEGFR2 functions as an H2S-targeting receptor protein kinase with its novel Cys1045-Cys1024 disulfide bond serving as a specific molecular switch for hydrogen sulfide actions in vascular endothelial cells.
Tao BB, Liu SY, Zhang CC, Fu W, Cai WJ, Wang Y, Shen Q, Wang MJ, Chen Y, Zhang LJ, Zhu YZ, Zhu YC. Tao BB, et al. Among authors: chen y. Antioxid Redox Signal. 2013 Aug 10;19(5):448-64. doi: 10.1089/ars.2012.4565. Epub 2013 Jan 28. Antioxid Redox Signal. 2013. PMID: 23199280 Free PMC article.
Protective Effects of Hydrogen Sulfide in the Ageing Kidney.
Hou CL, Wang MJ, Sun C, Huang Y, Jin S, Mu XP, Chen Y, Zhu YC. Hou CL, et al. Among authors: chen y. Oxid Med Cell Longev. 2016;2016:7570489. doi: 10.1155/2016/7570489. Epub 2016 Nov 1. Oxid Med Cell Longev. 2016. PMID: 27882191 Free PMC article.
Hydrogen sulfide functions as a micro-modulator bound at the copper active site of Cu/Zn-SOD to regulate the catalytic activity of the enzyme.
Wu DD, Jin S, Cheng RX, Cai WJ, Xue WL, Zhang QQ, Yang LJ, Zhu Q, Li MY, Lin G, Wang YZ, Mu XP, Wang Y, Zhang IY, Zhang Q, Chen Y, Cai SY, Tan B, Li Y, Chen YQ, Zhang PJ, Sun C, Yin Y, Wang MJ, Zhu YZ, Tao BB, Zhou JH, Huang WX, Zhu YC. Wu DD, et al. Among authors: chen yq, chen y. Cell Rep. 2023 Jul 25;42(7):112750. doi: 10.1016/j.celrep.2023.112750. Epub 2023 Jul 7. Cell Rep. 2023. PMID: 37421623 Free article.
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