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Transgenic expression of the HERV-W envelope protein leads to polarized glial cell populations and a neurodegenerative environment.
Gruchot J, Lewen I, Dietrich M, Reiche L, Sindi M, Hecker C, Herrero F, Charvet B, Weber-Stadlbauer U, Hartung HP, Albrecht P, Perron H, Meyer U, Küry P. Gruchot J, et al. Among authors: perron h. Proc Natl Acad Sci U S A. 2023 Sep 19;120(38):e2308187120. doi: 10.1073/pnas.2308187120. Epub 2023 Sep 11. Proc Natl Acad Sci U S A. 2023. PMID: 37695891 Free PMC article.
pHERV-W envelope protein fuels microglial cell-dependent damage of myelinated axons in multiple sclerosis.
Kremer D, Gruchot J, Weyers V, Oldemeier L, Göttle P, Healy L, Ho Jang J, Kang T Xu Y, Volsko C, Dutta R, Trapp BD, Perron H, Hartung HP, Küry P. Kremer D, et al. Among authors: perron h. Proc Natl Acad Sci U S A. 2019 Jul 23;116(30):15216-15225. doi: 10.1073/pnas.1901283116. Epub 2019 Jun 18. Proc Natl Acad Sci U S A. 2019. PMID: 31213545 Free PMC article.
Human Endogenous Retroviruses in Neurological Diseases.
Küry P, Nath A, Créange A, Dolei A, Marche P, Gold J, Giovannoni G, Hartung HP, Perron H. Küry P, et al. Among authors: perron h. Trends Mol Med. 2018 Apr;24(4):379-394. doi: 10.1016/j.molmed.2018.02.007. Epub 2018 Mar 15. Trends Mol Med. 2018. PMID: 29551251 Free PMC article. Review.
Meeting report: "Human endogenous retroviruses: HERVs or transposable elements in autoimmune, chronic inflammatory and degenerative diseases or cancer", Lyon, France, november 5th and 6th 2019 - an MS scientist's digest.
Kremer D, Weyers V, Gruchot J, Göttle P, Hartung HP, Perron H, Küry P. Kremer D, et al. Among authors: perron h. Mult Scler Relat Disord. 2020 Jul;42:102068. doi: 10.1016/j.msard.2020.102068. Epub 2020 Apr 8. Mult Scler Relat Disord. 2020. PMID: 32302965
A phase IIa randomized clinical study testing GNbAC1, a humanized monoclonal antibody against the envelope protein of multiple sclerosis associated endogenous retrovirus in multiple sclerosis patients - a twelve month follow-up.
Derfuss T, Curtin F, Guebelin C, Bridel C, Rasenack M, Matthey A, Du Pasquier R, Schluep M, Desmeules J, Lang AB, Perron H, Faucard R, Porchet H, Hartung HP, Kappos L, Lalive PH. Derfuss T, et al. Among authors: perron h. J Neuroimmunol. 2015 Aug 15;285:68-70. doi: 10.1016/j.jneuroim.2015.05.019. Epub 2015 May 20. J Neuroimmunol. 2015. PMID: 26198921 Clinical Trial.
103 results