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Cyanide Trapping of Iminium Ion Reactive Metabolites: Implications for Clinical Hepatotoxicity.
Chem Res Toxicol. 2024 May 20;37(5):698-710. doi: 10.1021/acs.chemrestox.3c00402. Epub 2024 Apr 15.
Chem Res Toxicol. 2024.
PMID: 38619497
3D human tissue models and microphysiological systems for HIV and related comorbidities.
3D Human Tissue Models for HIV Working Group. Electronic address: dwight.yin@nih.gov; 3D Human Tissue Models for HIV Working Group.
3D Human Tissue Models for HIV Working Group. Electronic address: dwight.yin@nih.gov, et al.
Trends Biotechnol. 2024 May;42(5):526-543. doi: 10.1016/j.tibtech.2023.10.008. Epub 2023 Dec 8.
Trends Biotechnol. 2024.
PMID: 38071144
Review.
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Considerations from an International Regulatory and Pharmaceutical Industry (IQ MPS Affiliate) Workshop on the Standardization of Complex In Vitro Models in Drug Development.
Tomlinson L, Ramsden D, Leite SB, Beken S, Bonzo JA, Brown P, Candarlioglu PL, Chan TS, Chen E, Choi CK, David R, Delrue N, Devine PJ, Ford K, Garcia MI, Gosset JR, Hewitt P, Homan K, Irrechukwu O, Kopec AK, Liras JL, Mandlekar S, Raczynski A, Sadrieh N, Sakatis MZ, Siegel J, Sung K, Sunyovszki I, Van Vleet TR, Ekert JE, Hardwick RN.
Tomlinson L, et al. Among authors: sakatis mz.
Adv Biol (Weinh). 2023 Oct 9:e2300131. doi: 10.1002/adbi.202300131. Online ahead of print.
Adv Biol (Weinh). 2023.
PMID: 37814378
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A blinded in vitro analysis of the intrinsic immunogenicity of hepatotoxic drugs: implications for preclinical risk assessment.
Ogese MO, Lister A, Farrell L, Gardner J, Kafu L, Ali SE, Gibson A, Hillegas A, Meng X, Pirmohamed M, Williams GS, Sakatis MZ, Naisbitt DJ.
Ogese MO, et al. Among authors: sakatis mz.
Toxicol Sci. 2023 Dec 21;197(1):38-52. doi: 10.1093/toxsci/kfad101.
Toxicol Sci. 2023.
PMID: 37788119
Free PMC article.
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Evaluation of a Three-Dimensional Primary Human Hepatocyte Spheroid Model: Adoption and Industrialization for the Enhanced Detection of Drug-Induced Liver Injury.
Schofield CA, Walker TM, Taylor MA, Patel M, Vlachou DF, Macina JM, Vidgeon-Hart MP, Williams A, McGill PJ, Newman CF, Sakatis MZ.
Schofield CA, et al. Among authors: sakatis mz.
Chem Res Toxicol. 2021 Dec 20;34(12):2485-2499. doi: 10.1021/acs.chemrestox.1c00227. Epub 2021 Nov 19.
Chem Res Toxicol. 2021.
PMID: 34797640
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Development of an Improved T-cell Assay to Assess the Intrinsic Immunogenicity of Haptenic Compounds.
Ogese MO, Watkinson J, Lister A, Faulkner L, Gibson A, Hillegas A, Sakatis MZ, Park BK, Naisbitt DJ.
Ogese MO, et al. Among authors: sakatis mz.
Toxicol Sci. 2020 Jun 1;175(2):266-278. doi: 10.1093/toxsci/kfaa034.
Toxicol Sci. 2020.
PMID: 32159798
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Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds.
Sakatis MZ, Reese MJ, Harrell AW, Taylor MA, Baines IA, Chen L, Bloomer JC, Yang EY, Ellens HM, Ambroso JL, Lovatt CA, Ayrton AD, Clarke SE.
Sakatis MZ, et al.
Chem Res Toxicol. 2012 Oct 15;25(10):2067-82. doi: 10.1021/tx300075j. Epub 2012 Sep 19.
Chem Res Toxicol. 2012.
PMID: 22931300
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A quantitative high-throughput trapping assay as a measurement of potential for bioactivation.
Meneses-Lorente G, Sakatis MZ, Schulz-Utermoehl T, De Nardi C, Watt AP.
Meneses-Lorente G, et al. Among authors: sakatis mz.
Anal Biochem. 2006 Apr 15;351(2):266-72. doi: 10.1016/j.ab.2006.01.016. Epub 2006 Jan 30.
Anal Biochem. 2006.
PMID: 16473319
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