Distelhorst CW - Search Results

1

A Novel Peptide that Disrupts the Lck-IP₃R Protein-Protein Interaction Induces Widespread Cell Death in Leukemia and Lymphoma.

Harr MW, Lavik A, McColl K, Zhong F, Haberer B, Aldabbagh K, Yee V, Distelhorst CW. Harr MW, et al. Among authors: distelhorst cw. Arch Microbiol Immunol. 2023;7(3):165-177. doi: 10.26502/ami.936500114. Epub 2023 Aug 30. Arch Microbiol Immunol. 2023. PMID: 37829571 Free PMC article.

2

A novel peptide that disrupts the Lck-IP3R protein-protein interaction induces widespread cell death in leukemia and lymphoma.

Harr M, Lavik A, McColl K, Zhong F, Haberer B, Aldabbagh K, Yee V, Distelhorst CW. Harr M, et al. Among authors: distelhorst cw. Res Sq [Preprint]. 2023 Jan 9:rs.3.rs-2436910. doi: 10.21203/rs.3.rs-2436910/v1. Res Sq. 2023. PMID: 36711753 Free PMC article. Updated. Preprint.

3

A non-canonical role for pyruvate kinase M2 as a functional modulator of Ca²⁺ signalling through IP₃ receptors.

Lavik AR, McColl KS, Lemos FO, Kerkhofs M, Zhong F, Harr M, Schlatzer D, Hamada K, Mikoshiba K, Crea F, Bultynck G, Bootman MD, Parys JB, Distelhorst CW. Lavik AR, et al. Among authors: distelhorst cw. Biochim Biophys Acta Mol Cell Res. 2022 Apr;1869(4):119206. doi: 10.1016/j.bbamcr.2021.119206. Epub 2022 Jan 11. Biochim Biophys Acta Mol Cell Res. 2022. PMID: 35026348 Free article.

4

Creating a New Cancer Therapeutic Agent by Targeting the Interaction between Bcl-2 and IP₃ Receptors.

Distelhorst CW, Bootman MD. Distelhorst CW, et al. Cold Spring Harb Perspect Biol. 2019 Sep 3;11(9):a035196. doi: 10.1101/cshperspect.a035196. Cold Spring Harb Perspect Biol. 2019. PMID: 31110129 Free PMC article. Review.

5

Targeting Bcl-2-IP₃ receptor interaction to treat cancer: A novel approach inspired by nearly a century treating cancer with adrenal corticosteroid hormones.

Distelhorst CW. Distelhorst CW. Biochim Biophys Acta Mol Cell Res. 2018 Nov;1865(11 Pt B):1795-1804. doi: 10.1016/j.bbamcr.2018.07.020. Epub 2018 Jul 25. Biochim Biophys Acta Mol Cell Res. 2018. PMID: 30053503 Free PMC article. Review.

6

Novel Protein Disulfide Isomerase Inhibitor with Anticancer Activity in Multiple Myeloma.

Vatolin S, Phillips JG, Jha BK, Govindgari S, Hu J, Grabowski D, Parker Y, Lindner DJ, Zhong F, Distelhorst CW, Smith MR, Cotta C, Xu Y, Chilakala S, Kuang RR, Tall S, Reu FJ. Vatolin S, et al. Among authors: distelhorst cw. Cancer Res. 2016 Jun 1;76(11):3340-50. doi: 10.1158/0008-5472.CAN-15-3099. Epub 2016 Apr 6. Cancer Res. 2016. PMID: 27197150

7

Synergistic killing of human small cell lung cancer cells by the Bcl-2-inositol 1,4,5-trisphosphate receptor disruptor BIRD-2 and the BH3-mimetic ABT-263.

Greenberg EF, McColl KS, Zhong F, Wildey G, Dowlati A, Distelhorst CW. Greenberg EF, et al. Among authors: distelhorst cw. Cell Death Dis. 2015 Dec 31;6(12):e2034. doi: 10.1038/cddis.2015.355. Cell Death Dis. 2015. PMID: 26720343 Free PMC article.

8

A synthetic peptide targeting the BH4 domain of Bcl-2 induces apoptosis in multiple myeloma and follicular lymphoma cells alone or in combination with agents targeting the BH3-binding pocket of Bcl-2.

Lavik AR, Zhong F, Chang MJ, Greenberg E, Choudhary Y, Smith MR, McColl KS, Pink J, Reu FJ, Matsuyama S, Distelhorst CW. Lavik AR, et al. Among authors: distelhorst cw. Oncotarget. 2015 Sep 29;6(29):27388-402. doi: 10.18632/oncotarget.4489. Oncotarget. 2015. PMID: 26317541 Free PMC article.

9

Acidosis Sensing Receptor GPR65 Correlates with Anti-Apoptotic Bcl-2 Family Member Expression in CLL Cells: Potential Implications for the CLL Microenvironment.

Rosko AE, McColl KS, Zhong F, Ryder CB, Chang MJ, Sattar A, Caimi PF, Hill BT, Al-Harbi S, Almasan A, Distelhorst CW. Rosko AE, et al. Among authors: distelhorst cw. J Leuk (Los Angel). 2014 Dec;2(5):160. doi: 10.4172/2329-6917.1000160. J Leuk (Los Angel). 2014. PMID: 25984552 Free PMC article.

10

Bcl-2 regulation of the inositol 1,4,5-trisphosphate receptor and calcium signaling in normal and malignant lymphocytes: potential new target for cancer treatment.

Greenberg EF, Lavik AR, Distelhorst CW. Greenberg EF, et al. Among authors: distelhorst cw. Biochim Biophys Acta. 2014 Oct;1843(10):2205-10. doi: 10.1016/j.bbamcr.2014.03.008. Epub 2014 Mar 15. Biochim Biophys Acta. 2014. PMID: 24642270 Free PMC article. Review.

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