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Best Practices for Microbial Challenge In-use Studies to Evaluate the Microbial Growth Potential of Parenteral Biological Products; Industry and Regulatory Considerations.
Zamiri C, Leiske DL, Hughes PF, Kirwan JP, Der E, Cox E, Warburton R, Goss M, Weiser S, Perez-Brown J, Gopalrathnam G, Liu J, Mehta SB, Shereefa S, Specht S, Aedo SJ, Goldbach P, Jia F, Kuehnle B, Page S, Voeten L, Yi L, Zhu C. Zamiri C, et al. Among authors: hughes pf. PDA J Pharm Sci Technol. 2023 Oct 17:pdajpst.2022.012806. doi: 10.5731/pdajpst.2022.012806. Online ahead of print. PDA J Pharm Sci Technol. 2023. PMID: 37848203
Microbial Risk in Pharmaceutical Manufacturing and ICH Q9.
Guilfoyle DE, Friedman RL, Hughes PF, Hussong D, Rosenberg AS, Brorson K. Guilfoyle DE, et al. Among authors: hughes pf. PDA J Pharm Sci Technol. 2013 Mar-Apr;67(2):79-80. doi: 10.5731/pdajpst.2013.00915. PDA J Pharm Sci Technol. 2013. PMID: 23569069 No abstract available.
TAK1 inhibition leads to RIPK1-dependent apoptosis in immune-activated cancers.
Damhofer H, Tatar T, Southgate B, Scarneo S, Agger K, Shlyueva D, Uhrbom L, Morrison GM, Hughes PF, Haystead T, Pollard SM, Helin K. Damhofer H, et al. Among authors: hughes pf. Cell Death Dis. 2024 Apr 17;15(4):273. doi: 10.1038/s41419-024-06654-1. Cell Death Dis. 2024. PMID: 38632238 Free PMC article.
Selective targeting of Plasmodium falciparum Hsp90 disrupts the 26S proteasome.
Mansfield CR, Quan B, Chirgwin ME, Eduful B, Hughes PF, Neveu G, Sylvester K, Ryan DH, Kafsack BFC, Haystead TAJ, Leahy JW, Fitzgerald MC, Derbyshire ER. Mansfield CR, et al. Among authors: hughes pf. Cell Chem Biol. 2024 Apr 18;31(4):729-742.e13. doi: 10.1016/j.chembiol.2024.02.008. Epub 2024 Mar 15. Cell Chem Biol. 2024. PMID: 38492573
Targeting Borrelia burgdorferi HtpG with a berserker molecule, a strategy for anti-microbial development.
Carlson DL, Kowalewski M, Bodoor K, Lietzan AD, Hughes PF, Gooden D, Loiselle DR, Alcorta D, Dingman Z, Mueller EA, Irnov I, Modla S, Chaya T, Caplan J, Embers M, Miller JC, Jacobs-Wagner C, Redinbo MR, Spector N, Haystead TAJ. Carlson DL, et al. Among authors: hughes pf. Cell Chem Biol. 2024 Mar 21;31(3):465-476.e12. doi: 10.1016/j.chembiol.2023.10.004. Epub 2023 Nov 1. Cell Chem Biol. 2024. PMID: 37918401 Free article.
Expression of membrane Hsp90 is a molecular signature of T cell activation.
Scarneo SA, Smith AP, Favret J, O'Connell R, Pickeral J, Yang KW, Ferrari G, Loiselle DR, Hughes PF, Kulkarni MM, Gargesha M, Scott B, Roy D, Haynes BF, Kwiek JJ, Haystead TAJ. Scarneo SA, et al. Among authors: hughes pf. Sci Rep. 2022 Oct 27;12(1):18091. doi: 10.1038/s41598-022-22788-8. Sci Rep. 2022. PMID: 36302951 Free PMC article.
Combination of a novel heat shock protein 90-targeted photodynamic therapy with PD-1/PD-L1 blockade induces potent systemic antitumor efficacy and abscopal effect against breast cancers.
Kaneko K, Acharya CR, Nagata H, Yang X, Hartman ZC, Hobeika A, Hughes PF, Haystead TAJ, Morse MA, Lyerly HK, Osada T. Kaneko K, et al. Among authors: hughes pf. J Immunother Cancer. 2022 Sep;10(9):e004793. doi: 10.1136/jitc-2022-004793. J Immunother Cancer. 2022. PMID: 36171008 Free PMC article.
59 results