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Diverse microtubule-targeted anticancer agents kill cells by inducing chromosome missegregation on multipolar spindles.
PLoS Biol. 2023 Oct 26;21(10):e3002339. doi: 10.1371/journal.pbio.3002339. eCollection 2023 Oct.
PLoS Biol. 2023.
PMID: 37883329
Free PMC article.
Chromosomal instability sensitizes patient breast tumors to multipolar divisions induced by paclitaxel.
Scribano CM, Wan J, Esbona K, Tucker JB, Lasek A, Zhou AS, Zasadil LM, Molini R, Fitzgerald J, Lager AM, Laffin JJ, Correia-Staudt K, Wisinski KB, Tevaarwerk AJ, O'Regan R, McGregor SM, Fowler AM, Chappell RJ, Bugni TS, Burkard ME, Weaver BA.
Scribano CM, et al.
Sci Transl Med. 2021 Sep 8;13(610):eabd4811. doi: 10.1126/scitranslmed.abd4811. Epub 2021 Sep 8.
Sci Transl Med. 2021.
PMID: 34516829
Free PMC article.
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Paclitaxel Induces Micronucleation and Activates Pro-Inflammatory cGAS-STING Signaling in Triple-Negative Breast Cancer.
Hu Y, Manasrah BK, McGregor SM, Lera RF, Norman RX, Tucker JB, Scribano CM, Yan RE, Humayun M, Wisinski KB, Tevaarwerk AJ, O'Regan RM, Wilke LG, Weaver BA, Beebe DJ, Jin N, Burkard ME.
Hu Y, et al. Among authors: scribano cm.
Mol Cancer Ther. 2021 Dec;20(12):2553-2567. doi: 10.1158/1535-7163.MCT-21-0195. Epub 2021 Sep 28.
Mol Cancer Ther. 2021.
PMID: 34583980
Free PMC article.
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Mad1 destabilizes p53 by preventing PML from sequestering MDM2.
Wan J, Block S, Scribano CM, Thiry R, Esbona K, Audhya A, Weaver BA.
Wan J, et al. Among authors: scribano cm.
Nat Commun. 2019 Apr 4;10(1):1540. doi: 10.1038/s41467-019-09471-9.
Nat Commun. 2019.
PMID: 30948704
Free PMC article.
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