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The bone marrow is the primary site of thrombopoiesis.
Asquith NL, Carminita E, Camacho V, Rodriguez-Romera A, Stegner D, Freire D, Becker IC, Machlus KR, Khan AO, Italiano JE. Asquith NL, et al. Among authors: machlus kr. Blood. 2024 Jan 18;143(3):272-278. doi: 10.1182/blood.2023020895. Blood. 2024. PMID: 37879046
Peripheral megakaryocytes sound the alarm in COVID-19.
Boilard E, Machlus KR. Boilard E, et al. Among authors: machlus kr. Blood Adv. 2023 Aug 8;7(15):4197-4199. doi: 10.1182/bloodadvances.2023010201. Blood Adv. 2023. PMID: 37552512 Free PMC article. No abstract available.
Spatial transcriptomics of murine bone marrow megakaryocytes at single-cell resolution.
Tilburg J, Stone AP, Billingsley JM, Scoville DK, Pavenko A, Liang Y, Italiano JE Jr, Machlus KR. Tilburg J, et al. Among authors: machlus kr. Res Pract Thromb Haemost. 2023 Apr 20;7(4):100158. doi: 10.1016/j.rpth.2023.100158. eCollection 2023 May. Res Pract Thromb Haemost. 2023. PMID: 37255850 Free PMC article.
Efficient megakaryopoiesis and platelet production require phospholipid remodeling and PUFA uptake through CD36.
Barrachina MN, Pernes G, Becker IC, Allaeys I, Hirsch TI, Groeneveld DJ, Khan AO, Freire D, Guo K, Carminita E, Morgan PK, Collins TJ, Mellett NA, Wei Z, Almazni I, Italiano JE, Luyendyk J, Meikle PJ, Puder M, Morgan NV, Boilard E, Murphy AJ, Machlus KR. Barrachina MN, et al. Among authors: machlus kr. bioRxiv [Preprint]. 2023 Feb 12:2023.02.12.527706. doi: 10.1101/2023.02.12.527706. bioRxiv. 2023. PMID: 36798332 Free PMC article. Updated. Preprint.
Human Bone Marrow Organoids for Disease Modeling, Discovery, and Validation of Therapeutic Targets in Hematologic Malignancies.
Khan AO, Rodriguez-Romera A, Reyat JS, Olijnik AA, Colombo M, Wang G, Wen WX, Sousos N, Murphy LC, Grygielska B, Perrella G, Mahony CB, Ling RE, Elliott NE, Karali CS, Stone AP, Kemble S, Cutler EA, Fielding AK, Croft AP, Bassett D, Poologasundarampillai G, Roy A, Gooding S, Rayes J, Machlus KR, Psaila B. Khan AO, et al. Among authors: machlus kr. Cancer Discov. 2023 Feb 6;13(2):364-385. doi: 10.1158/2159-8290.CD-22-0199. Cancer Discov. 2023. PMID: 36351055 Free PMC article.
58 results