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Bis-aryl-α,β-unsaturated ketone (ABK) chaperonin inhibitors exhibit selective cytotoxicity to colorectal cancer cells that correlates with levels of aberrant HSP60 in the cytosol.
Chitre S, Ray AM, Stevens M, Doud EH, Liechty H, Washburn A, Tepper K, Sivinski J, O'Hagan HM, Georgiadis MM, Chapman E, Johnson SM. Chitre S, et al. Among authors: georgiadis mm. Bioorg Med Chem. 2022 Dec 1;75:117072. doi: 10.1016/j.bmc.2022.117072. Epub 2022 Oct 30. Bioorg Med Chem. 2022. PMID: 36356534
New Ref-1/APE1 targeted inhibitors demonstrating improved potency for clinical applications in multiple cancer types.
Gampala S, Moon HR, Wireman R, Peil J, Kiran S, Mitchell DK, Brewster K, Mang H, Masters A, Bach C, Smith-Kinnamen W, Doud EH, Rai R, Mosley AL, Quinney SK, Clapp DW, Hamdouchi C, Wikel J, Zhang C, Han B, Georgiadis MM, Kelley MR, Fishel ML. Gampala S, et al. Among authors: georgiadis mm. Pharmacol Res. 2024 Mar;201:107092. doi: 10.1016/j.phrs.2024.107092. Epub 2024 Feb 2. Pharmacol Res. 2024. PMID: 38311014 Free PMC article.
In vitro and In vivo evidence demonstrating chronic absence of Ref-1 Cysteine 65 impacts Ref-1 folding configuration, redox signaling, proliferation and metastasis in pancreatic cancer.
Mijit M, Kpenu E, Chowdhury NN, Gampala S, Wireman R, Liu S, Babb O, Georgiadis MM, Wan J, Fishel ML, Kelley MR. Mijit M, et al. Among authors: georgiadis mm. Redox Biol. 2024 Feb;69:102977. doi: 10.1016/j.redox.2023.102977. Epub 2023 Dec 1. Redox Biol. 2024. PMID: 38056311 Free PMC article.
Activation of Gcn2 by small molecules designed to be inhibitors.
Carlson KR, Georgiadis MM, Tameire F, Staschke KA, Wek RC. Carlson KR, et al. Among authors: georgiadis mm. J Biol Chem. 2023 Apr;299(4):104595. doi: 10.1016/j.jbc.2023.104595. Epub 2023 Mar 8. J Biol Chem. 2023. PMID: 36898579 Free PMC article.
Crystal structures of 'ALternative Isoinformational ENgineered' DNA in B-form.
Shukla MS, Hoshika S, Benner SA, Georgiadis MM. Shukla MS, et al. Among authors: georgiadis mm. Philos Trans R Soc Lond B Biol Sci. 2023 Feb 27;378(1871):20220028. doi: 10.1098/rstb.2022.0028. Epub 2023 Jan 11. Philos Trans R Soc Lond B Biol Sci. 2023. PMID: 36633282 Free PMC article.
74 results