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Synthesis of sulfated alginate from its tributylammonium salt: Comparing the sulfating agents H2SO4-DCC and SO3·py.
Mutch AL, Ferro V, A A, Grøndahl L. Mutch AL, et al. Among authors: a a. Carbohydr Polym. 2024 Jan 15;324:121488. doi: 10.1016/j.carbpol.2023.121488. Epub 2023 Oct 14. Carbohydr Polym. 2024. PMID: 37985083
This study involving three researchers used the tributylammonium salt of alginate (T-Alg) as a common substrate for the sulfation reactions. It was found that the use of H(2)SO(4)-DCC resulted in poor control of the degree of sulfation (DS) and that the S-Alg polymers cont …
This study involving three researchers used the tributylammonium salt of alginate (T-Alg) as a common substrate for the sulfation rea …
Evaluation of the in vivo fate of ultrapure alginate in a BALB/c mouse model.
A A, Fletcher NL, Houston ZH, Thurecht KJ, Grøndahl L. A A, et al. Carbohydr Polym. 2021 Jun 15;262:117947. doi: 10.1016/j.carbpol.2021.117947. Epub 2021 Mar 16. Carbohydr Polym. 2021. PMID: 33838824
The current study therefore evaluates the biodistribution of ultrapure ALG (M/G ratio 0.67 with a measured M(w) of 530 kg/mol and polydispersity index; PDI of 1.49) over a 14-day period in BALB/c mice. ...This extended biodistribution study confirmed the clearance o …
The current study therefore evaluates the biodistribution of ultrapure ALG (M/G ratio 0.67 with a measured M(w) of 530 kg/mol and pol …
Chitosan Nanomedicine in Cancer Therapy: Targeted Delivery and Cellular Uptake.
Mushtaq A, Li L, A A, Grøndahl L. Mushtaq A, et al. Among authors: a a. Macromol Biosci. 2021 May;21(5):e2100005. doi: 10.1002/mabi.202100005. Epub 2021 Mar 19. Macromol Biosci. 2021. PMID: 33738977 Review.
A total of 23 studies are analyzed for cellular uptake including 12 studies reporting cellular uptake mechanisms. ...It is concluded based on the recent literature available on chitosan particles that combination therapies can play a pivotal role in transformation o …
A total of 23 studies are analyzed for cellular uptake including 12 studies reporting cellular uptake mechanisms. ...It is concluded …
Characterisation of products from EDC-mediated PEG substitution of chitosan allows optimisation of reaction conditions.
Mushtaq A, Li L, A A, Grøndahl L. Mushtaq A, et al. Among authors: a a. Int J Biol Macromol. 2022 Nov 30;221:204-211. doi: 10.1016/j.ijbiomac.2022.08.179. Epub 2022 Sep 1. Int J Biol Macromol. 2022. PMID: 36058393
PEGylation is a common method use to modify the physiochemical properties and increase the solubility of chitosan (CHI). ...Within the parameter space investigated, optimised reaction conditions (NH(2): COOH:NHS:EDC of 3.5:1:1:10, pH = 5) resulted in a DS of 24 % an …
PEGylation is a common method use to modify the physiochemical properties and increase the solubility of chitosan (CHI). ...Within th …
Targeted Nanoparticles Based on Alendronate Polyethylene Glycol Conjugated Chitosan for the Delivery of siRNA and Curcumin for Bone Metastasized Breast Cancer Applications.
Mushtaq A, Li L, Grøndahl L, A A. Mushtaq A, et al. Among authors: a a. Macromol Biosci. 2024 Feb;24(2):e2300268. doi: 10.1002/mabi.202300268. Epub 2023 Oct 15. Macromol Biosci. 2024. PMID: 37794635
Targeted delivery of small interfering RNA (siRNA) and chemotherapeutic drugs using nanoparticles (NPs) is a promising strategy to overcome current limitations in treating these metastatic breast cancers. ...
Targeted delivery of small interfering RNA (siRNA) and chemotherapeutic drugs using nanoparticles (NPs) is a promising strategy to ov …
Evaluation of surface layer stability of surface-modified polyester biomaterials.
Poli H, Mutch AL, A A, Ivanovski S, Vaquette C, Castner DG, Gómez-Cerezo MN, Grøndahl L. Poli H, et al. Among authors: a a. Biointerphases. 2020 Dec 4;15(6):061010. doi: 10.1116/6.0000687. Biointerphases. 2020. PMID: 33276701 Free PMC article.
Surface modification of biomaterials is a strategy used to improve cellular and in vivo outcomes. However, most studies do not evaluate the lifetime of the introduced surface layer, which is an important aspect affecting how a biomaterial will interact with a …
Surface modification of biomaterials is a strategy used to improve cellular and in vivo outcomes. However, most studies do not evalua …
Protein adsorption to poly(tetrafluoroethylene) membranes modified with grafted poly(acrylic acid) chains.
Mohd Hidzir N, A A, Kępa K, Hill DJT, Jorgensen L, Grøndahl L. Mohd Hidzir N, et al. Among authors: a a. Biointerphases. 2020 Jun 11;15(3):031011. doi: 10.1116/6.0000137. Biointerphases. 2020. PMID: 32527100
The current study evaluated five solid surfaces with poly(acrylic acid) (PAA) grafted from the surface of a poly(tetrafluoroethylene) membrane with respect to the adsorption of serum albumin (SA), lactoferrin (Lf), and lysozyme (Lys) from a phosphate buffer and NaCl …
The current study evaluated five solid surfaces with poly(acrylic acid) (PAA) grafted from the surface of a poly(tetrafluoroethylene) …
Antibody and T-cell response to bivalent booster SARS-CoV-2 vaccines in people with compromised immune function (COVERALL-3).
Amstutz A, Chammartin F, Audigé A, Eichenberger AL, Braun DL, Amico P, Stoeckle MP, Hasse B, Papadimitriou-Olivgeris M, Manuel O, Bongard C, Schuurmans MM, Hage R, Damm D, Tamm M, Mueller NJ, Rauch A, Günthard HF, Koller MT, Schönenberger CM, Griessbach A, Labhardt ND, Kouyos RD, Trkola A, Kusejko K, Bucher HC, Abela IA, Briel M, Speich B; Swiss HIV Cohort Study; Swiss Transplant Cohort Study. Amstutz A, et al. J Infect Dis. 2024 Jun 7:jiae291. doi: 10.1093/infdis/jiae291. Online ahead of print. J Infect Dis. 2024. PMID: 38848312
197 results