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Anomalous peroxidase activity of cytochrome c is the primary pathogenic target in Barth syndrome.
Kagan VE, Tyurina YY, Mikulska-Ruminska K, Damschroder D, Vieira Neto E, Lasorsa A, Kapralov AA, Tyurin VA, Amoscato AA, Samovich SN, Souryavong AB, Dar HH, Ramim A, Liang Z, Lazcano P, Ji J, Schmidtke MW, Kiselyov K, Korkmaz A, Vladimirov GK, Artyukhova MA, Rampratap P, Cole LK, Niyatie A, Baker EK, Peterson J, Hatch GM, Atkinson J, Vockley J, Kühn B, Wessells R, van der Wel PCA, Bahar I, Bayir H, Greenberg ML. Kagan VE, et al. Among authors: kapralov aa. Nat Metab. 2023 Dec;5(12):2184-2205. doi: 10.1038/s42255-023-00926-4. Epub 2023 Nov 23. Nat Metab. 2023. PMID: 37996701
Discovering selective antiferroptotic inhibitors of the 15LOX/PEBP1 complex noninterfering with biosynthesis of lipid mediators.
Dar HH, Mikulska-Ruminska K, Tyurina YY, Luci DK, Yasgar A, Samovich SN, Kapralov AA, Souryavong AB, Tyurin VA, Amoscato AA, Epperly MW, Shurin GV, Standley M, Holman TR, St Croix CM, Watkins SC, VanDemark AP, Rana S, Zakharov AV, Simeonov A, Marugan J, Mallampalli RK, Wenzel SE, Greenberger JS, Rai G, Bayir H, Bahar I, Kagan VE. Dar HH, et al. Among authors: kapralov aa. Proc Natl Acad Sci U S A. 2023 Jun 20;120(25):e2218896120. doi: 10.1073/pnas.2218896120. Epub 2023 Jun 16. Proc Natl Acad Sci U S A. 2023. PMID: 37327313 Free PMC article.
Strikingly High Activity of 15-Lipoxygenase Towards Di-Polyunsaturated Arachidonoyl/Adrenoyl-Phosphatidylethanolamines Generates Peroxidation Signals of Ferroptotic Cell Death.
Samovich SN, Mikulska-Ruminska K, Dar HH, Tyurina YY, Tyurin VA, Souryavong AB, Kapralov AA, Amoscato AA, Beharier O, Karumanchi SA, St Croix CM, Yang X, Holman TR, VanDemark AP, Sadovsky Y, Mallampalli RK, Wenzel SE, Gu W, Bunimovich YL, Bahar I, Kagan VE, Bayir H. Samovich SN, et al. Among authors: kapralov aa. Angew Chem Int Ed Engl. 2024 Feb 26;63(9):e202314710. doi: 10.1002/anie.202314710. Epub 2024 Jan 17. Angew Chem Int Ed Engl. 2024. PMID: 38230815
Redox phospholipidomics discovers pro-ferroptotic death signals in A375 melanoma cells in vitro and in vivo.
Tyurina YY, Kapralov AA, Tyurin VA, Shurin G, Amoscato AA, Rajasundaram D, Tian H, Bunimovich YL, Nefedova Y, Herrick WG, Parchment RE, Doroshow JH, Bayir H, Srivastava AK, Kagan VE. Tyurina YY, et al. Among authors: kapralov aa. Redox Biol. 2023 May;61:102650. doi: 10.1016/j.redox.2023.102650. Epub 2023 Feb 28. Redox Biol. 2023. PMID: 36870109 Free PMC article.
Inactivation of RIP3 kinase sensitizes to 15LOX/PEBP1-mediated ferroptotic death.
Lamade AM, Wu L, Dar HH, Mentrup HL, Shrivastava IH, Epperly MW, St Croix CM, Tyurina YY, Anthonymuthu TS, Yang Q, Kapralov AA, Huang Z, Mao G, Amoscato AA, Hier ZE, Artyukhova MA, Shurin G, Rosenbaum JC, Gough PJ, Bertin J, VanDemark AP, Watkins SC, Mollen KP, Bahar I, Greenberger JS, Kagan VE, Whalen MJ, Bayır H. Lamade AM, et al. Among authors: kapralov aa. Redox Biol. 2022 Apr;50:102232. doi: 10.1016/j.redox.2022.102232. Epub 2022 Jan 10. Redox Biol. 2022. PMID: 35101798 Free PMC article.
P. aeruginosa augments irradiation injury via 15-lipoxygenase-catalyzed generation of 15-HpETE-PE and induction of theft-ferroptosis.
Dar HH, Epperly MW, Tyurin VA, Amoscato AA, Anthonymuthu TS, Souryavong AB, Kapralov AA, Shurin GV, Samovich SN, St Croix CM, Watkins SC, Wenzel SE, Mallampalli RK, Greenberger JS, Bayır H, Kagan VE, Tyurina YY. Dar HH, et al. Among authors: kapralov aa. JCI Insight. 2022 Feb 22;7(4):e156013. doi: 10.1172/jci.insight.156013. JCI Insight. 2022. PMID: 35041620 Free PMC article.
79 results