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Editing the core region in HPFH deletions alters fetal and adult globin expression for treatment of β-hemoglobinopathies.
Venkatesan V, Christopher AC, Rhiel M, Azhagiri MKK, Babu P, Walavalkar K, Saravanan B, Andrieux G, Rangaraj S, Srinivasan S, Karuppusamy KV, Jacob A, Bagchi A, Pai AA, Nakamura Y, Kurita R, Balasubramanian P, Pai R, Marepally SK, Mohankumar KM, Velayudhan SR, Boerries M, Notani D, Cathomen T, Srivastava A, Thangavel S. Venkatesan V, et al. Among authors: notani d. Mol Ther Nucleic Acids. 2023 Apr 26;32:671-688. doi: 10.1016/j.omtn.2023.04.024. eCollection 2023 Jun 13. Mol Ther Nucleic Acids. 2023. PMID: 37215154 Free PMC article.
First glimpse of enhancers in gene regulation.
Notani D. Notani D. Nat Rev Genet. 2022 Sep;23(9):522-523. doi: 10.1038/s41576-022-00492-7. Nat Rev Genet. 2022. PMID: 35478013 No abstract available.
Testing the super-enhancer concept.
Blobel GA, Higgs DR, Mitchell JA, Notani D, Young RA. Blobel GA, et al. Among authors: notani d. Nat Rev Genet. 2021 Dec;22(12):749-755. doi: 10.1038/s41576-021-00398-w. Epub 2021 Sep 3. Nat Rev Genet. 2021. PMID: 34480110 No abstract available.
34 results