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129 results

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Page 1
Senotherapeutic drug treatment ameliorates chemotherapy-induced cachexia.
Englund DA, Jolliffe AM, Hanson GJ, Aversa Z, Zhang X, Jiang X, White TA, Zhang L, Monroe DG, Robbins PD, Niedernhofer LJ, Kamenecka TM, Khosla S, LeBrasseur NK. Englund DA, et al. Among authors: kamenecka tm. JCI Insight. 2024 Jan 23;9(2):e169512. doi: 10.1172/jci.insight.169512. JCI Insight. 2024. PMID: 38051584 Free PMC article.
Small molecules targeting selective PCK1 and PGC-1α lysine acetylation cause anti-diabetic action through increased lactate oxidation.
Mutlu B, Sharabi K, Sohn JH, Yuan B, Latorre-Muro P, Qin X, Yook JS, Lin H, Yu D, Camporez JPG, Kajimura S, Shulman GI, Hui S, Kamenecka TM, Griffin PR, Puigserver P. Mutlu B, et al. Among authors: kamenecka tm. Cell Chem Biol. 2024 Oct 17;31(10):1772-1786.e5. doi: 10.1016/j.chembiol.2024.09.001. Epub 2024 Sep 27. Cell Chem Biol. 2024. PMID: 39341205
PPARγ Corepression Involves Alternate Ligand Conformation and Inflation of H12 Ensembles.
Frkic RL, Pederick JL, Horsfall AJ, Jovcevski B, Crame EE, Kowalczyk W, Pukala TL, Chang MR, Zheng J, Blayo AL, Abell AD, Kamenecka TM, Harbort JS, Harmer JR, Griffin PR, Bruning JB. Frkic RL, et al. Among authors: kamenecka tm. ACS Chem Biol. 2023 May 19;18(5):1115-1123. doi: 10.1021/acschembio.2c00917. Epub 2023 May 5. ACS Chem Biol. 2023. PMID: 37146157
SR9883 is a novel small-molecule enhancer of α4β2* nicotinic acetylcholine receptor signaling that decreases intravenous nicotine self-administration in rats.
Braunscheidel KM, Voren G, Fowler CD, Lu Q, Kuryatov A, Cameron MD, Ibañez-Tallon I, Lindstrom JM, Kamenecka TM, Kenny PJ. Braunscheidel KM, et al. Among authors: kamenecka tm. Front Mol Neurosci. 2024 Sep 5;17:1459098. doi: 10.3389/fnmol.2024.1459098. eCollection 2024. Front Mol Neurosci. 2024. PMID: 39346680 Free PMC article.
Development of Clinically Viable Non-Muscle Myosin II Small Molecule Inhibitors with Broad Therapeutic Potential.
Radnai L, Young EJ, Kikuti C, Hafenbreidel M, Stremel RF, Lin L, Toth K, Pasetto P, Jin X, Patel A, Conlon M, Briggs S, Heidsieck L, Sweeney HL, Sellers J, Krieger-Burke T, Martin WH, Sisco J, Young S, Pearson P, Rumbaugh G, Araldi GL, Duddy SK, Cameron MD, Surman M, Houdusse A, Griffin PR, Kamenecka TM, Miller CA. Radnai L, et al. Among authors: kamenecka tm. bioRxiv [Preprint]. 2024 Oct 12:2024.10.07.617018. doi: 10.1101/2024.10.07.617018. bioRxiv. 2024. PMID: 39416074 Free PMC article. Preprint.
MT-125 Inhibits Non-Muscle Myosin IIA and IIB, Synergizes with Oncogenic Kinase Inhibitors, and Prolongs Survival in Glioblastoma.
Kenchappa R, Radnai L, Young EJ, Zarco N, Lin L, Dovas A, Meyer CT, Haddock A, Hall A, Canoll P, Cameron MD, Nagaiah NK, Rumbaugh G, Griffin PR, Kamenecka TM, Miller CA, Rosenfeld SS. Kenchappa R, et al. Among authors: kamenecka tm. bioRxiv [Preprint]. 2024 Apr 29:2024.04.27.591399. doi: 10.1101/2024.04.27.591399. bioRxiv. 2024. PMID: 38746089 Free PMC article. Preprint.
High throughput screening for compounds to the orphan nuclear receptor NR2F6.
Smith E, Campbell S, Wilson AN, Shumate J, Baillargeon P, Scampavia L, Kamenecka TM, Spicer TP, Solt LA. Smith E, et al. Among authors: kamenecka tm. SLAS Discov. 2022 Jun;27(4):242-248. doi: 10.1016/j.slasd.2022.03.005. Epub 2022 Mar 21. SLAS Discov. 2022. PMID: 35331960 Free PMC article.
129 results