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Discovery of Clinical Candidate AZD5462, a Selective Oral Allosteric RXFP1 Agonist for Treatment of Heart Failure.
Granberg KL, Sakamaki S, Larsson N, Bergström F, Fuchigami R, Niwa Y, Ryberg E, Backmark A, Kato H, Miyazaki S, Iguchi K, Sakamoto T, Persson M, Idei A, Prieto Garcia L, Villar IC, Gradén H, Bergonzini G, Arvidsson T, Fujita T, Althage M, Ulander J, Kimura J, Yoneda H, Fjellström O, Mochida H, Lal M. Granberg KL, et al. Among authors: althage m. J Med Chem. 2024 Mar 28;67(6):4419-4441. doi: 10.1021/acs.jmedchem.3c02184. Epub 2024 Mar 19. J Med Chem. 2024. PMID: 38502782
Identification of Novel Series of Potent and Selective Relaxin Family Peptide Receptor 1 (RXFP1) Agonists.
Granberg KL, Sakamaki S, Fuchigami R, Niwa Y, Fujio M, Kato H, Bergström F, Larsson N, Persson M, Villar IC, Fujita T, Sugikawa E, Althage M, Yano N, Yokoyama Y, Kimura J, Lal M, Mochida H. Granberg KL, et al. Among authors: althage m. J Med Chem. 2024 Mar 28;67(6):4442-4462. doi: 10.1021/acs.jmedchem.3c02183. Epub 2024 Mar 19. J Med Chem. 2024. PMID: 38502780
Efficacy and safety of zibotentan and dapagliflozin in patients with chronic kidney disease: study design and baseline characteristics of the ZENITH-CKD trial.
Heerspink HJL, Greasley PJ, Ahlström C, Althage M, Dwyer JP, Law G, Wijkmark E, Lin M, Mercier AK, Sunnåker M, Turton M, Wheeler DC, Ambery P. Heerspink HJL, et al. Among authors: althage m. Nephrol Dial Transplant. 2024 Feb 28;39(3):414-425. doi: 10.1093/ndt/gfad183. Nephrol Dial Transplant. 2024. PMID: 37632201 Free PMC article. Clinical Trial.
Endothelin-1 is increased in the plasma of patients hospitalised with Covid-19.
Abraham GR, Kuc RE, Althage M, Greasley PJ, Ambery P, Maguire JJ, Wilkinson IB, Hoole SP, Cheriyan J, Davenport AP. Abraham GR, et al. Among authors: althage m. J Mol Cell Cardiol. 2022 Jun;167:92-96. doi: 10.1016/j.yjmcc.2022.03.007. Epub 2022 Mar 23. J Mol Cell Cardiol. 2022. PMID: 35339512 Free PMC article.
Urine APOL1 Isoforms Reflect Plasma-Derived Liver-Synthesized Proteins.
Althage M, Heinrich TM, Miliotis T, Bogstedt A, Ma L, Gautreaux MD, Hicks PJ, Palmer ND, MacPhee I, Hartleib-Geschwindner J, Greasley PJ, Freedman BI. Althage M, et al. J Am Soc Nephrol. 2021 Oct;32(10):2442-2444. doi: 10.1681/ASN.2021030411. Epub 2021 Jun 23. J Am Soc Nephrol. 2021. PMID: 34162735 Free PMC article. No abstract available.
Identification and analyses of inhibitors targeting apolipoprotein(a) kringle domains KIV-7, KIV-10, and KV provide insight into kringle domain function.
Sandmark J, Tigerström A, Akerud T, Althage M, Antonsson T, Blaho S, Bodin C, Boström J, Chen Y, Dahlén A, Eriksson PO, Evertsson E, Fex T, Fjellström O, Gustafsson D, Herslöf M, Hicks R, Jarkvist E, Johansson C, Kalies I, Karlsson Svalstedt B, Kartberg F, Legnehed A, Martinsson S, Moberg A, Ridderström M, Rosengren B, Sabirsh A, Thelin A, Vinblad J, Wellner AU, Xu B, Östlund-Lindqvist AM, Knecht W. Sandmark J, et al. Among authors: althage m. J Biol Chem. 2020 Apr 10;295(15):5136-5151. doi: 10.1074/jbc.RA119.011251. Epub 2020 Mar 4. J Biol Chem. 2020. PMID: 32132173 Free PMC article.
26 results