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High-content multimodal analysis supports the IL-7/IL-7 receptor axis as a relevant therapeutic target in primary Sjögren's syndrome.
Desvaux E, Hemon P, Soret P, Le Dantec C, Chatzis L, Cornec D, Devauchelle-Pensec V; PRECISESADS clinical consortium; Elouej S, Duguet F, Laigle L, Poirier N, Moingeon P, Bretin S, Pers JO. Desvaux E, et al. Among authors: poirier n. J Autoimmun. 2023 Dec 18:103147. doi: 10.1016/j.jaut.2023.103147. Online ahead of print. J Autoimmun. 2023. PMID: 38114349
Interleukin-7/Interferon Axis Drives T Cell and Salivary Gland Epithelial Cell Interactions in Sjögren's Syndrome.
Rivière E, Pascaud J, Virone A, Dupré A, Ly B, Paoletti A, Seror R, Tchitchek N, Mingueneau M, Smith N, Duffy D, Cassard L, Chaput N, Pengam S, Gauttier V, Poirier N, Mariette X, Nocturne G. Rivière E, et al. Among authors: poirier n. Arthritis Rheumatol. 2021 Apr;73(4):631-640. doi: 10.1002/art.41558. Epub 2021 Feb 15. Arthritis Rheumatol. 2021. PMID: 33058491
IL-7 receptor blockade blunts antigen-specific memory T cell responses and chronic inflammation in primates.
Belarif L, Mary C, Jacquemont L, Mai HL, Danger R, Hervouet J, Minault D, Thepenier V, Nerrière-Daguin V, Nguyen E, Pengam S, Largy E, Delobel A, Martinet B, Le Bas-Bernardet S, Brouard S, Soulillou JP, Degauque N, Blancho G, Vanhove B, Poirier N. Belarif L, et al. Among authors: poirier n. Nat Commun. 2018 Oct 26;9(1):4483. doi: 10.1038/s41467-018-06804-y. Nat Commun. 2018. PMID: 30367166 Free PMC article.
IL-7 receptor influences anti-TNF responsiveness and T cell gut homing in inflammatory bowel disease.
Belarif L, Danger R, Kermarrec L, Nerrière-Daguin V, Pengam S, Durand T, Mary C, Kerdreux E, Gauttier V, Kucik A, Thepenier V, Martin JC, Chang C, Rahman A, Guen NS, Braudeau C, Abidi A, David G, Malard F, Takoudju C, Martinet B, Gérard N, Neveu I, Neunlist M, Coron E, MacDonald TT, Desreumaux P, Mai HL, Le Bas-Bernardet S, Mosnier JF, Merad M, Josien R, Brouard S, Soulillou JP, Blancho G, Bourreille A, Naveilhan P, Vanhove B, Poirier N. Belarif L, et al. Among authors: poirier n. J Clin Invest. 2019 Apr 2;129(5):1910-1925. doi: 10.1172/JCI121668. eCollection 2019 Apr 2. J Clin Invest. 2019. PMID: 30939120 Free PMC article.
CLEC-1 is a death sensor that limits antigen cross-presentation by dendritic cells and represents a target for cancer immunotherapy.
Drouin M, Saenz J, Gauttier V, Evrard B, Teppaz G, Pengam S, Mary C, Desselle A, Thepenier V, Wilhelm E, Merieau E, Ligeron C, Girault I, Lopez MD, Fourgeux C, Sinha D, Baccelli I, Moreau A, Louvet C, Josien R, Poschmann J, Poirier N, Chiffoleau E. Drouin M, et al. Among authors: poirier n. Sci Adv. 2022 Nov 16;8(46):eabo7621. doi: 10.1126/sciadv.abo7621. Epub 2022 Nov 18. Sci Adv. 2022. PMID: 36399563 Free PMC article.
253 results