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Cholesterol redistribution triggered by CYP46A1 gene therapy improves major hallmarks of Niemann-Pick type C disease but is not sufficient to halt neurodegeneration.
Nunes MJ, Carvalho AN, Reis J, Costa D, Moutinho M, Mateus J, Mendes de Almeida R, Brito S, Risso D, Nunes S, Castro-Caldas M, Gama MJ, Rodrigues CMP, Xapelli S, Diógenes MJ, Cartier N, Chali F, Piguet F, Rodrigues E. Nunes MJ, et al. Among authors: diogenes mj. Biochim Biophys Acta Mol Basis Dis. 2024 Mar;1870(3):166993. doi: 10.1016/j.bbadis.2023.166993. Epub 2023 Dec 22. Biochim Biophys Acta Mol Basis Dis. 2024. PMID: 38142760 Free article.
Adenosinergic System and BDNF Signaling Changes as a Cross-Sectional Feature of RTT: Characterization of Mecp2 Heterozygous Mouse Females.
Miranda-Lourenço C, Rosa J, Rei N, Belo RF, Lopes AL, Silva D, Vieira C, Magalhães-Cardoso T, Viais R, Correia-de-Sá P, Sebastião AM, Diógenes MJ. Miranda-Lourenço C, et al. Among authors: diogenes mj. Int J Mol Sci. 2023 Nov 13;24(22):16249. doi: 10.3390/ijms242216249. Int J Mol Sci. 2023. PMID: 38003438 Free PMC article.
S327 phosphorylation of the presynaptic protein SEPTIN5 increases in the early stages of neurofibrillary pathology and alters the functionality of SEPTIN5.
Ferreira CB, Marttinen M, Coelho JE, Paldanius KMA, Takalo M, Mäkinen P, Leppänen L, Miranda-Lourenço C, Fonseca-Gomes J, Tanqueiro SR, Vaz SH, Belo RF, Sebastião AM, Leinonen V, Soininen H, Pike I, Haapasalo A, Lopes LV, de Mendonça A, Diógenes MJ, Hiltunen M. Ferreira CB, et al. Among authors: diogenes mj. Neurobiol Dis. 2022 Feb;163:105603. doi: 10.1016/j.nbd.2021.105603. Epub 2021 Dec 24. Neurobiol Dis. 2022. PMID: 34954322 Free article.
High Caloric Diet Induces Memory Impairment and Disrupts Synaptic Plasticity in Aged Rats.
Paulo SL, Miranda-Lourenço C, Belo RF, Rodrigues RS, Fonseca-Gomes J, Tanqueiro SR, Geraldes V, Rocha I, Sebastião AM, Xapelli S, Diógenes MJ. Paulo SL, et al. Among authors: diogenes mj. Curr Issues Mol Biol. 2021 Dec 18;43(3):2305-2319. doi: 10.3390/cimb43030162. Curr Issues Mol Biol. 2021. PMID: 34940136 Free PMC article.
Sustained NMDA receptor hypofunction impairs brain-derived neurotropic factor signalling in the PFC, but not in the hippocampus, and disturbs PFC-dependent cognition in mice.
Tanqueiro SR, Mouro FM, Ferreira CB, Freitas CF, Fonseca-Gomes J, Simões do Couto F, Sebastião AM, Dawson N, Diógenes MJ. Tanqueiro SR, et al. Among authors: diogenes mj. J Psychopharmacol. 2021 Jun;35(6):730-743. doi: 10.1177/02698811211008560. Epub 2021 May 19. J Psychopharmacol. 2021. PMID: 34008450
In vivo Bio-Distribution and Toxicity Evaluation of Polymeric and Lipid-Based Nanoparticles: A Potential Approach for Chronic Diseases Treatment.
Fonseca-Gomes J, Loureiro JA, Tanqueiro SR, Mouro FM, Ruivo P, Carvalho T, Sebastião AM, Diógenes MJ, Pereira MC. Fonseca-Gomes J, et al. Among authors: diogenes mj. Int J Nanomedicine. 2020 Nov 5;15:8609-8621. doi: 10.2147/IJN.S267007. eCollection 2020. Int J Nanomedicine. 2020. PMID: 33177821 Free PMC article.
60 results