Nagai Y - Search Results

1

Lysophagy protects against propagation of α-synuclein aggregation through ruptured lysosomal vesicles.

Kakuda K, Ikenaka K, Kuma A, Doi J, Aguirre C, Wang N, Ajiki T, Choong CJ, Kimura Y, Badawy SMM, Shima T, Nakamura S, Baba K, Nagano S, Nagai Y, Yoshimori T, Mochizuki H. Kakuda K, et al. Among authors: nagai y. Proc Natl Acad Sci U S A. 2024 Jan 2;121(1):e2312306120. doi: 10.1073/pnas.2312306120. Epub 2023 Dec 26. Proc Natl Acad Sci U S A. 2024. PMID: 38147546 Free PMC article.

2

Synchrotron FTIR micro-spectroscopy for structural analysis of Lewy bodies in the brain of Parkinson's disease patients.

Araki K, Yagi N, Ikemoto Y, Yagi H, Choong CJ, Hayakawa H, Beck G, Sumi H, Fujimura H, Moriwaki T, Nagai Y, Goto Y, Mochizuki H. Araki K, et al. Among authors: nagai y. Sci Rep. 2015 Dec 1;5:17625. doi: 10.1038/srep17625. Sci Rep. 2015. PMID: 26621077 Free PMC article.

3

A small-angle X-ray scattering study of alpha-synuclein from human red blood cells.

Araki K, Yagi N, Nakatani R, Sekiguchi H, So M, Yagi H, Ohta N, Nagai Y, Goto Y, Mochizuki H. Araki K, et al. Among authors: nagai y. Sci Rep. 2016 Jul 29;6:30473. doi: 10.1038/srep30473. Sci Rep. 2016. PMID: 27469540 Free PMC article.

4

Pathological role of lipid interaction with α-synuclein in Parkinson's disease.

Suzuki M, Sango K, Wada K, Nagai Y. Suzuki M, et al. Among authors: nagai y. Neurochem Int. 2018 Oct;119:97-106. doi: 10.1016/j.neuint.2017.12.014. Epub 2018 Jan 3. Neurochem Int. 2018. PMID: 29305919 Free article. Review.

5

Parkinson's disease-linked DNAJC13 mutation aggravates alpha-synuclein-induced neurotoxicity through perturbation of endosomal trafficking.

Yoshida S, Hasegawa T, Suzuki M, Sugeno N, Kobayashi J, Ueyama M, Fukuda M, Ido-Fujibayashi A, Sekiguchi K, Ezura M, Kikuchi A, Baba T, Takeda A, Mochizuki H, Nagai Y, Aoki M. Yoshida S, et al. Among authors: nagai y. Hum Mol Genet. 2018 Mar 1;27(5):823-836. doi: 10.1093/hmg/ddy003. Hum Mol Genet. 2018. PMID: 29309590

6

Ultrasonication-based rapid amplification of α-synuclein aggregates in cerebrospinal fluid.

Kakuda K, Ikenaka K, Araki K, So M, Aguirre C, Kajiyama Y, Konaka K, Noi K, Baba K, Tsuda H, Nagano S, Ohmichi T, Nagai Y, Tokuda T, El-Agnaf OMA, Ogi H, Goto Y, Mochizuki H. Kakuda K, et al. Among authors: nagai y. Sci Rep. 2019 Apr 12;9(1):6001. doi: 10.1038/s41598-019-42399-0. Sci Rep. 2019. PMID: 30979935 Free PMC article.

7

E46K mutant α-synuclein is more degradation resistant and exhibits greater toxic effects than wild-type α-synuclein in Drosophila models of Parkinson's disease.

Sakai R, Suzuki M, Ueyama M, Takeuchi T, Minakawa EN, Hayakawa H, Baba K, Mochizuki H, Nagai Y. Sakai R, et al. Among authors: nagai y. PLoS One. 2019 Jun 26;14(6):e0218261. doi: 10.1371/journal.pone.0218261. eCollection 2019. PLoS One. 2019. PMID: 31242217 Free PMC article.

8

Arylsulfatase A, a genetic modifier of Parkinson's disease, is an α-synuclein chaperone.

Lee JS, Kanai K, Suzuki M, Kim WS, Yoo HS, Fu Y, Kim DK, Jung BC, Choi M, Oh KW, Li Y, Nakatani M, Nakazato T, Sekimoto S, Funayama M, Yoshino H, Kubo SI, Nishioka K, Sakai R, Ueyama M, Mochizuki H, Lee HJ, Sardi SP, Halliday GM, Nagai Y, Lee PH, Hattori N, Lee SJ. Lee JS, et al. Among authors: nagai y. Brain. 2019 Sep 1;142(9):2845-2859. doi: 10.1093/brain/awz205. Brain. 2019. PMID: 31312839

9

Lipids as Trans-Acting Effectors for α-Synuclein in the Pathogenesis of Parkinson's Disease.

Ikenaka K, Suzuki M, Mochizuki H, Nagai Y. Ikenaka K, et al. Among authors: nagai y. Front Neurosci. 2019 Jul 3;13:693. doi: 10.3389/fnins.2019.00693. eCollection 2019. Front Neurosci. 2019. PMID: 31333408 Free PMC article. Review.

10

Parkinson's disease is a type of amyloidosis featuring accumulation of amyloid fibrils of α-synuclein.

Araki K, Yagi N, Aoyama K, Choong CJ, Hayakawa H, Fujimura H, Nagai Y, Goto Y, Mochizuki H. Araki K, et al. Among authors: nagai y. Proc Natl Acad Sci U S A. 2019 Sep 3;116(36):17963-17969. doi: 10.1073/pnas.1906124116. Epub 2019 Aug 19. Proc Natl Acad Sci U S A. 2019. PMID: 31427526 Free PMC article.

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