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Perfluorinated Iridium Catalyst for Signal Amplification by Reversible Exchange Provides Metal-Free Aqueous Hyperpolarized [1-13C]-Pyruvate.
Ettedgui J, Blackman B, Raju N, Kotler SA, Chekmenev EY, Goodson BM, Merkle H, Woodroofe CC, LeClair CA, Krishna MC, Swenson RE. Ettedgui J, et al. Among authors: leclair ca. J Am Chem Soc. 2024 Jan 10;146(1):946-953. doi: 10.1021/jacs.3c11499. Epub 2023 Dec 28. J Am Chem Soc. 2024. PMID: 38154120 Free PMC article.
Comparative Analysis of Drug-like EP300/CREBBP Acetyltransferase Inhibitors.
Crawford MC, Tripu DR, Barritt SA, Jing Y, Gallimore D, Kales SC, Bhanu NV, Xiong Y, Fang Y, Butler KAT, LeClair CA, Coussens NP, Simeonov A, Garcia BA, Dibble CC, Meier JL. Crawford MC, et al. Among authors: leclair ca. ACS Chem Biol. 2023 Oct 20;18(10):2249-2258. doi: 10.1021/acschembio.3c00293. Epub 2023 Sep 22. ACS Chem Biol. 2023. PMID: 37737090 Free PMC article.
A Universal and High-Throughput Proteomics Sample Preparation Platform.
Burns AP, Zhang YQ, Xu T, Wei Z, Yao Q, Fang Y, Cebotaru V, Xia M, Hall MD, Huang R, Simeonov A, LeClair CA, Tao D. Burns AP, et al. Among authors: leclair ca. Anal Chem. 2021 Jun 22;93(24):8423-8431. doi: 10.1021/acs.analchem.1c00265. Epub 2021 Jun 10. Anal Chem. 2021. PMID: 34110797 Free PMC article.
Discovery of Novel Small-Molecule Scaffolds for the Inhibition and Activation of WIP1 Phosphatase from a RapidFire Mass Spectrometry High-Throughput Screen.
Clausse V, Fang Y, Tao D, Tagad HD, Sun H, Wang Y, Karavadhi S, Lane K, Shi ZD, Vasalatiy O, LeClair CA, Eells R, Shen M, Patnaik S, Appella E, Coussens NP, Hall MD, Appella DH. Clausse V, et al. Among authors: leclair ca. ACS Pharmacol Transl Sci. 2022 Sep 28;5(10):993-1006. doi: 10.1021/acsptsci.2c00147. eCollection 2022 Oct 14. ACS Pharmacol Transl Sci. 2022. PMID: 36268125 Free PMC article.
An approach to rapid distributed manufacturing of broad spectrum anti-viral griffithsin using cell-free systems to mitigate pandemics.
Borhani SG, Levine MZ, Krumpe LH, Wilson J, Henrich CJ, O'Keefe BR, Lo DC, Sittampalam GS, Godfrey AG, Lunsford RD, Mangalampalli V, Tao D, LeClair CA, Thole AP, Frey D, Swartz J, Rao G. Borhani SG, et al. Among authors: leclair ca. N Biotechnol. 2023 Sep 25;76:13-22. doi: 10.1016/j.nbt.2023.04.003. Epub 2023 Apr 11. N Biotechnol. 2023. PMID: 37054948 Free PMC article.
Structure-Based Optimization of Small Molecule Human Galactokinase Inhibitors.
Liu L, Tang M, Pragani R, Whitby FG, Zhang YQ, Balakrishnan B, Fang Y, Karavadhi S, Tao D, LeClair CA, Hall MD, Marugan JJ, Boxer M, Shen M, Hill CP, Lai K, Patnaik S. Liu L, et al. Among authors: leclair ca. J Med Chem. 2021 Sep 23;64(18):13551-13571. doi: 10.1021/acs.jmedchem.1c00945. Epub 2021 Sep 7. J Med Chem. 2021. PMID: 34491744 Free PMC article.
High-throughput combinatorial screening identifies drugs that cooperate with ibrutinib to kill activated B-cell-like diffuse large B-cell lymphoma cells.
Mathews Griner LA, Guha R, Shinn P, Young RM, Keller JM, Liu D, Goldlust IS, Yasgar A, McKnight C, Boxer MB, Duveau DY, Jiang JK, Michael S, Mierzwa T, Huang W, Walsh MJ, Mott BT, Patel P, Leister W, Maloney DJ, Leclair CA, Rai G, Jadhav A, Peyser BD, Austin CP, Martin SE, Simeonov A, Ferrer M, Staudt LM, Thomas CJ. Mathews Griner LA, et al. Among authors: leclair ca. Proc Natl Acad Sci U S A. 2014 Feb 11;111(6):2349-54. doi: 10.1073/pnas.1311846111. Epub 2014 Jan 27. Proc Natl Acad Sci U S A. 2014. PMID: 24469833 Free PMC article.
Comparative analysis of drug-like EP300/CREBBP acetyltransferase inhibitors.
Crawford MC, Tripu DR, Barritt SA, Jing Y, Gallimore D, Kales SC, Bhanu NV, Xiong Y, Fang Y, Butler KAT, LeClair CA, Coussens NP, Simeonov A, Garcia BA, Dibble CC, Meier JL. Crawford MC, et al. Among authors: leclair ca. bioRxiv [Preprint]. 2023 May 16:2023.05.15.540887. doi: 10.1101/2023.05.15.540887. bioRxiv. 2023. PMID: 37292747 Free PMC article. Updated. Preprint.
27 results