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Oncogenic KEAP1 mutations activate TRAF2-NFκB signaling to prevent apoptosis in lung cancer cells.
Deen AJ, Adinolfi S, Härkönen J, Patinen T, Liu X, Laitinen T, Takabe P, Kainulainen K, Pasonen-Seppänen S, Gawriyski LM, Arasu UT, Selvarajan I, Mäkinen P, Laitinen H, Kansanen E, Kaikkonen MU, Poso A, Varjosalo M, Levonen AL. Deen AJ, et al. Among authors: laitinen t, laitinen h. Redox Biol. 2024 Feb;69:103031. doi: 10.1016/j.redox.2024.103031. Epub 2024 Jan 4. Redox Biol. 2024. PMID: 38184997 Free PMC article.
Comparative and pharmacophore model for deacetylase SIRT1.
Huhtiniemi T, Wittekindt C, Laitinen T, Leppänen J, Salminen A, Poso A, Lahtela-Kakkonen M. Huhtiniemi T, et al. Among authors: laitinen t. J Comput Aided Mol Des. 2006 Sep;20(9):589-99. doi: 10.1007/s10822-006-9084-9. Epub 2006 Nov 11. J Comput Aided Mol Des. 2006. PMID: 17103016
Molecular dynamics simulations for human CAR inverse agonists.
Jyrkkärinne J, Küblbeck J, Pulkkinen J, Honkakoski P, Laatikainen R, Poso A, Laitinen T. Jyrkkärinne J, et al. Among authors: laitinen t. J Chem Inf Model. 2012 Feb 27;52(2):457-64. doi: 10.1021/ci200432k. Epub 2012 Jan 25. J Chem Inf Model. 2012. PMID: 22233089
Piperazine and piperidine triazole ureas as ultrapotent and highly selective inhibitors of monoacylglycerol lipase.
Aaltonen N, Savinainen JR, Ribas CR, Rönkkö J, Kuusisto A, Korhonen J, Navia-Paldanius D, Häyrinen J, Takabe P, Käsnänen H, Pantsar T, Laitinen T, Lehtonen M, Pasonen-Seppänen S, Poso A, Nevalainen T, Laitinen JT. Aaltonen N, et al. Among authors: laitinen t, laitinen jt. Chem Biol. 2013 Mar 21;20(3):379-90. doi: 10.1016/j.chembiol.2013.01.012. Chem Biol. 2013. PMID: 23521796
Peptides and Pseudopeptides as SIRT6 Deacetylation Inhibitors.
Kokkonen P, Rahnasto-Rilla M, Kiviranta PH, Huhtiniemi T, Laitinen T, Poso A, Jarho E, Lahtela-Kakkonen M. Kokkonen P, et al. Among authors: laitinen t. ACS Med Chem Lett. 2012 Oct 23;3(12):969-74. doi: 10.1021/ml300139n. eCollection 2012 Dec 13. ACS Med Chem Lett. 2012. PMID: 24900419 Free PMC article.
570 results