Appu AP - Search Results

1

Disruption of lysosomal nutrient sensing scaffold contributes to pathogenesis of a fatal neurodegenerative lysosomal storage disease.

Bagh MB, Appu AP, Sadhukhan T, Mondal A, Plavelil N, Raghavankutty M, Supran AM, Sadhukhan S, Liu A, Mukherjee AB. Bagh MB, et al. Among authors: appu ap. J Biol Chem. 2024 Feb;300(2):105641. doi: 10.1016/j.jbc.2024.105641. Epub 2024 Jan 9. J Biol Chem. 2024. PMID: 38211816 Free PMC article.

2

Acss2 Deletion Reveals Functional Versatility via Tissue-Specific Roles in Transcriptional Regulation.

Vasudevan NP, Soni DK, Moffett JR, Krishnan JKS, Appu AP, Ghoshal S, Arun P, Denu JM, Flagg TP, Biswas R, Namboodiri AM. Vasudevan NP, et al. Among authors: appu ap. Int J Mol Sci. 2023 Feb 12;24(4):3673. doi: 10.3390/ijms24043673. Int J Mol Sci. 2023. PMID: 36835088 Free PMC article.

3

Ppt1-deficiency dysregulates lysosomal Ca⁺⁺ homeostasis contributing to pathogenesis in a mouse model of CLN1 disease.

Mondal A, Appu AP, Sadhukhan T, Bagh MB, Previde RM, Sadhukhan S, Stojilkovic S, Liu A, Mukherjee AB. Mondal A, et al. Among authors: appu ap. J Inherit Metab Dis. 2022 May;45(3):635-656. doi: 10.1002/jimd.12485. Epub 2022 Mar 17. J Inherit Metab Dis. 2022. PMID: 35150145 Free PMC article.

4

Potential innovation against Alzheimer's disorder: a tricomponent combination of natural antioxidants (vitamin E, quercetin, and basil oil) and the development of its intranasal delivery.

Karthika C, Appu AP, Akter R, Rahman MH, Tagde P, Ashraf GM, Abdel-Daim MM, Hassan SSU, Abid A, Bungau S. Karthika C, et al. Among authors: appu ap. Environ Sci Pollut Res Int. 2022 Feb;29(8):10950-10965. doi: 10.1007/s11356-021-17830-7. Epub 2022 Jan 9. Environ Sci Pollut Res Int. 2022. PMID: 35000160 Review.

5

Ablation of microRNA-155 and neuroinflammation in a mouse model of CLN1-disease.

Sadhukhan T, Bagh MB, Sadhukhan S, Appu AP, Mondal A, Iiben JR, Li T, Coon SL, Mukherjee AB. Sadhukhan T, et al. Among authors: appu ap. Biochem Biophys Res Commun. 2021 Sep 24;571:137-144. doi: 10.1016/j.bbrc.2021.07.057. Epub 2021 Jul 26. Biochem Biophys Res Commun. 2021. PMID: 34325129

6

In a mouse model of INCL reduced S-palmitoylation of cytosolic thioesterase APT1 contributes to microglia proliferation and neuroinflammation.

Sadhukhan T, Bagh MB, Appu AP, Mondal A, Zhang W, Liu A, Mukherjee AB. Sadhukhan T, et al. Among authors: appu ap. J Inherit Metab Dis. 2021 Jul;44(4):1051-1069. doi: 10.1002/jimd.12379. Epub 2021 Mar 29. J Inherit Metab Dis. 2021. PMID: 33739454

7

Cln1-mutations suppress Rab7-RILP interaction and impair autophagy contributing to neuropathology in a mouse model of infantile neuronal ceroid lipofuscinosis.

Sarkar C, Sadhukhan T, Bagh MB, Appu AP, Chandra G, Mondal A, Saha A, Mukherjee AB. Sarkar C, et al. Among authors: appu ap. J Inherit Metab Dis. 2020 Sep;43(5):1082-1101. doi: 10.1002/jimd.12242. Epub 2020 Apr 27. J Inherit Metab Dis. 2020. PMID: 32279353 Free PMC article.

8

Cln3-mutations underlying juvenile neuronal ceroid lipofuscinosis cause significantly reduced levels of Palmitoyl-protein thioesterases-1 (Ppt1)-protein and Ppt1-enzyme activity in the lysosome.

Appu AP, Bagh MB, Sadhukhan T, Mondal A, Casey S, Mukherjee AB. Appu AP, et al. J Inherit Metab Dis. 2019 Sep;42(5):944-954. doi: 10.1002/jimd.12106. Epub 2019 May 14. J Inherit Metab Dis. 2019. PMID: 31025705 Free PMC article.

9

Emerging new roles of the lysosome and neuronal ceroid lipofuscinoses.

Mukherjee AB, Appu AP, Sadhukhan T, Casey S, Mondal A, Zhang Z, Bagh MB. Mukherjee AB, et al. Among authors: appu ap. Mol Neurodegener. 2019 Jan 16;14(1):4. doi: 10.1186/s13024-018-0300-6. Mol Neurodegener. 2019. PMID: 30651094 Free PMC article. Review.

10

Brief isoflurane administration as a post-exposure treatment for organophosphate poisoning.

Krishnan JKS, Figueiredo TH, Moffett JR, Arun P, Appu AP, Puthillathu N, Braga MF, Flagg T, Namboodiri AM. Krishnan JKS, et al. Among authors: appu ap. Neurotoxicology. 2017 Dec;63:84-89. doi: 10.1016/j.neuro.2017.09.009. Epub 2017 Sep 20. Neurotoxicology. 2017. PMID: 28939237

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