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Targeted macrophage phagocytosis by Irg1/itaconate axis improves the prognosis of intracerebral hemorrhagic stroke and peritonitis.
Luo Z, Sheng Z, Hu L, Shi L, Tian Y, Zhao X, Yang W, Xiao Z, Shen D, Wu W, Lan T, Zhao B, Wang X, Zhuang N, Zhang JN, Wang Y, Lu Y, Wang L, Zhang C, Wang P, An J, Yang F, Li Q. Luo Z, et al. Among authors: xiao z. EBioMedicine. 2024 Mar;101:104993. doi: 10.1016/j.ebiom.2024.104993. Epub 2024 Feb 6. EBioMedicine. 2024. PMID: 38324982 Free PMC article.
IRG1/itaconate increases IL-10 release to alleviate mechanical and thermal hypersensitivity in mice after nerve injury.
Sun Q, Hu T, Zhang Y, Wang X, Liu J, Chen W, Wei C, Liu D, Wu W, Lan T, Ding Y, Luo Z, Liu M, Shen D, Xiao Z, Hu L, Pang M, Ma Y, Shi L, Wang P, Zhang J, Li Q, Yang F. Sun Q, et al. Among authors: xiao z. Front Immunol. 2022 Oct 13;13:1012442. doi: 10.3389/fimmu.2022.1012442. eCollection 2022. Front Immunol. 2022. PMID: 36311727 Free PMC article.
Inhibition of the LRRC8A channel promotes microglia/macrophage phagocytosis and improves outcomes after intracerebral hemorrhagic stroke.
Liu J, Shen D, Wei C, Wu W, Luo Z, Hu L, Xiao Z, Hu T, Sun Q, Wang X, Ding Y, Liu M, Pang M, Gai K, Ma Y, Tian Y, Yu Y, Wang P, Guan Y, Xu M, Yang F, Li Q. Liu J, et al. Among authors: xiao z. iScience. 2022 Nov 13;25(12):105527. doi: 10.1016/j.isci.2022.105527. eCollection 2022 Dec 22. iScience. 2022. PMID: 36465125 Free PMC article.
H3K9 trimethylation dictates neuronal ferroptosis through repressing Tfr1.
Lan T, Hu L, Sun T, Wang X, Xiao Z, Shen D, Wu W, Luo Z, Wei C, Wang X, Liu M, Guo Y, Wang L, Wang Y, Lu Y, Yu Y, Yang F, Zhang C, Li Q. Lan T, et al. Among authors: xiao z. J Cereb Blood Flow Metab. 2023 Aug;43(8):1365-1381. doi: 10.1177/0271678X231165653. Epub 2023 Mar 24. J Cereb Blood Flow Metab. 2023. PMID: 36960698 Free PMC article.
Itaconate protects ferroptotic neurons by alkylating GPx4 post stroke.
Wei C, Xiao Z, Zhang Y, Luo Z, Liu D, Hu L, Shen D, Liu M, Shi L, Wang X, Lan T, Dai Q, Liu J, Chen W, Zhang Y, Sun Q, Wu W, Wang P, Zhang C, Hu J, Wang C, Yang F, Li Q. Wei C, et al. Among authors: xiao z. Cell Death Differ. 2024 May 8. doi: 10.1038/s41418-024-01303-8. Online ahead of print. Cell Death Differ. 2024. PMID: 38719928
8,147 results