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Dynamics and cytokinic regulation of immune cell infiltration in genetically engineered mouse models of pancreatic cancer dictate the sensitivity to immunotherapy.
Safak O, Wang S, Mota Reyes C, Gürcinar IH, Tokalov S, Cevik NC, Görgülü K, Yilmaz BS, Erdogan E, Ye L, Li Q, Sever EA, Özer S, Süyen G, Friess H, Ceyhan GO, Istvanffy R, Algül H, Demir IE. Safak O, et al. Among authors: gorgulu k. Cancer Commun (Lond). 2024 Jan;44(1):178-182. doi: 10.1002/cac2.12496. Epub 2023 Oct 25. Cancer Commun (Lond). 2024. PMID: 37877813 Free PMC article. No abstract available.
Phenotype screens of murine pancreatic cancer identify a Tgf-α-Ccl2-paxillin axis driving human-like neural invasion.
Wang X, Istvanffy R, Ye L, Teller S, Laschinger M, Diakopoulos KN, Görgülü K, Li Q, Ren L, Jäger C, Steiger K, Muckenhuber A, Vilne B, Çifcibaşı K, Reyes CM, Yurteri Ü, Kießler M, Gürçınar IH, Sugden M, Yıldızhan SE, Sezerman OU, Çilingir S, Süyen G, Reichert M, Schmid RM, Bärthel S, Oellinger R, Krüger A, Rad R, Saur D, Algül H, Friess H, Lesina M, Ceyhan GO, Demir IE. Wang X, et al. Among authors: gorgulu k. J Clin Invest. 2023 Nov 1;133(21):e166333. doi: 10.1172/JCI166333. J Clin Invest. 2023. PMID: 37607005 Free PMC article.
Extensive preclinical validation of combined RMC-4550 and LY3214996 supports clinical investigation for KRAS mutant pancreatic cancer.
Frank KJ, Mulero-Sánchez A, Berninger A, Ruiz-Cañas L, Bosma A, Görgülü K, Wu N, Diakopoulos KN, Kaya-Aksoy E, Ruess DA, Kabacaoğlu D, Schmidt F, Kohlmann L, van Tellingen O, Thijssen B, van de Ven M, Proost N, Kossatz S, Weber WA, Sainz B Jr, Bernards R, Algül H, Lesina M, Mainardi S. Frank KJ, et al. Among authors: gorgulu k. Cell Rep Med. 2022 Nov 15;3(11):100815. doi: 10.1016/j.xcrm.2022.100815. Cell Rep Med. 2022. PMID: 36384095 Free PMC article.
A guide to preprinting for early-career researchers.
Ettinger CL, Sadanandappa MK, Görgülü K, Coghlan KL, Hallenbeck KK, Puebla I. Ettinger CL, et al. Among authors: gorgulu k. Biol Open. 2022 Jul 15;11(7):bio059310. doi: 10.1242/bio.059310. Epub 2022 Jul 25. Biol Open. 2022. PMID: 35876380 Free PMC article.
Macrophages direct cancer cells through a LOXL2-mediated metastatic cascade in pancreatic ductal adenocarcinoma.
Alonso-Nocelo M, Ruiz-Cañas L, Sancho P, Görgülü K, Alcalá S, Pedrero C, Vallespinos M, López-Gil JC, Ochando M, García-García E, David Trabulo SM, Martinelli P, Sánchez-Tomero P, Sánchez-Palomo C, Gonzalez-Santamaría P, Yuste L, Wörmann SM, Kabacaoğlu D, Earl J, Martin A, Salvador F, Valle S, Martin-Hijano L, Carrato A, Erkan M, García-Bermejo L, Hermann PC, Algül H, Moreno-Bueno G, Heeschen C, Portillo F, Cano A, Sainz B , Jr. Alonso-Nocelo M, et al. Among authors: gorgulu k. Gut. 2023 Feb;72(2):345-359. doi: 10.1136/gutjnl-2021-325564. Epub 2022 Apr 15. Gut. 2023. PMID: 35428659 Free PMC article.
An anti-tumor coup: TIM3 ablation activates the immune arsenal.
Görgülü K, Kabacaoğlu D, Algül H. Görgülü K, et al. Signal Transduct Target Ther. 2021 Sep 27;6(1):348. doi: 10.1038/s41392-021-00757-3. Signal Transduct Target Ther. 2021. PMID: 34580280 Free PMC article. No abstract available.
Future directions in preclinical and translational cancer neuroscience research.
Demir IE, Mota Reyes C, Alrawashdeh W, Ceyhan GO, Deborde S, Friess H, Görgülü K, Istvanffy R, Jungwirth D, Kuner R, Maryanovich M, Na'ara S, Renders S, Saloman JL, Scheff NN, Steenfadt H, Stupakov P, Thiel V, Verma D, Yilmaz BS, White RA, Wang TC, Wong RJ, Frenette PS, Gil Z; Neural Influences in Cancer (NIC) International Research Consortium; Davis BM. Demir IE, et al. Among authors: gorgulu k. Nat Cancer. 2021 Nov;1:1027-1031. doi: 10.1038/s43018-020-00146-9. Epub 2020 Nov 17. Nat Cancer. 2021. PMID: 34327335 Free PMC article.
25 results