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Targeting the chromatin binding of exportin-1 disrupts NFAT and T cell activation.
Chen YF, Ghazala M, Friedrich RM, Cordova BA, Petroze FN, Srinivasan R, Allan KC, Yan DF, Sax JL, Carr K, Tomchuck SL, Fedorov Y, Huang AY, Desai AB, Adams DJ. Chen YF, et al. Among authors: sax jl. Nat Chem Biol. 2024 Mar 25. doi: 10.1038/s41589-024-01586-5. Online ahead of print. Nat Chem Biol. 2024. PMID: 38528120
Accumulation of 8,9-unsaturated sterols drives oligodendrocyte formation and remyelination.
Hubler Z, Allimuthu D, Bederman I, Elitt MS, Madhavan M, Allan KC, Shick HE, Garrison E, T Karl M, Factor DC, Nevin ZS, Sax JL, Thompson MA, Fedorov Y, Jin J, Wilson WK, Giera M, Bracher F, Miller RH, Tesar PJ, Adams DJ. Hubler Z, et al. Among authors: sax jl. Nature. 2018 Aug;560(7718):372-376. doi: 10.1038/s41586-018-0360-3. Epub 2018 Jul 25. Nature. 2018. PMID: 30046109 Free PMC article.
Engineering site-selective incorporation of fluorine into polyketides.
Sirirungruang S, Ad O, Privalsky TM, Ramesh S, Sax JL, Dong H, Baidoo EEK, Amer B, Khosla C, Chang MCY. Sirirungruang S, et al. Among authors: sax jl. Nat Chem Biol. 2022 Aug;18(8):886-893. doi: 10.1038/s41589-022-01070-y. Epub 2022 Jul 11. Nat Chem Biol. 2022. PMID: 35817967 Free PMC article.