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Phosphatidylserine-exposing extracellular vesicles in body fluids are an innate defence against apoptotic mimicry viral pathogens.
Groß R, Reßin H, von Maltitz P, Albers D, Schneider L, Bley H, Hoffmann M, Cortese M, Gupta D, Deniz M, Choi JY, Jansen J, Preußer C, Seehafer K, Pöhlmann S, Voelker DR, Goffinet C, Pogge-von Strandmann E, Bunz U, Bartenschlager R, El Andaloussi S, Sparrer KMJ, Herker E, Becker S, Kirchhoff F, Münch J, Müller JA. Groß R, et al. Among authors: sparrer kmj. Nat Microbiol. 2024 Apr;9(4):905-921. doi: 10.1038/s41564-024-01637-6. Epub 2024 Mar 25. Nat Microbiol. 2024. PMID: 38528146 Free PMC article.
SIVcol Nef counteracts SERINC5 by promoting its proteasomal degradation but does not efficiently enhance HIV-1 replication in human CD4+ T cells and lymphoid tissue.
Kmiec D, Akbil B, Ananth S, Hotter D, Sparrer KMJ, Stürzel CM, Trautz B, Ayouba A, Peeters M, Yao Z, Stagljar I, Passos V, Zillinger T, Goffinet C, Sauter D, Fackler OT, Kirchhoff F. Kmiec D, et al. Among authors: sparrer kmj. PLoS Pathog. 2018 Aug 20;14(8):e1007269. doi: 10.1371/journal.ppat.1007269. eCollection 2018 Aug. PLoS Pathog. 2018. PMID: 30125328 Free PMC article.
Guanylate-Binding Proteins 2 and 5 Exert Broad Antiviral Activity by Inhibiting Furin-Mediated Processing of Viral Envelope Proteins.
Braun E, Hotter D, Koepke L, Zech F, Groß R, Sparrer KMJ, Müller JA, Pfaller CK, Heusinger E, Wombacher R, Sutter K, Dittmer U, Winkler M, Simmons G, Jakobsen MR, Conzelmann KK, Pöhlmann S, Münch J, Fackler OT, Kirchhoff F, Sauter D. Braun E, et al. Among authors: sparrer kmj. Cell Rep. 2019 May 14;27(7):2092-2104.e10. doi: 10.1016/j.celrep.2019.04.063. Cell Rep. 2019. PMID: 31091448 Free article.
Vpu modulates DNA repair to suppress innate sensing and hyper-integration of HIV-1.
Volcic M, Sparrer KMJ, Koepke L, Hotter D, Sauter D, Stürzel CM, Scherer M, Stamminger T, Hofmann TG, Arhel NJ, Wiesmüller L, Kirchhoff F. Volcic M, et al. Among authors: sparrer kmj. Nat Microbiol. 2020 Oct;5(10):1247-1261. doi: 10.1038/s41564-020-0753-6. Epub 2020 Jul 20. Nat Microbiol. 2020. PMID: 32690953
An enzyme-based immunodetection assay to quantify SARS-CoV-2 infection.
Conzelmann C, Gilg A, Groß R, Schütz D, Preising N, Ständker L, Jahrsdörfer B, Schrezenmeier H, Sparrer KMJ, Stamminger T, Stenger S, Münch J, Müller JA. Conzelmann C, et al. Among authors: sparrer kmj. Antiviral Res. 2020 Sep;181:104882. doi: 10.1016/j.antiviral.2020.104882. Epub 2020 Jul 29. Antiviral Res. 2020. PMID: 32738255 Free PMC article.
Supramolecular Mechanism of Viral Envelope Disruption by Molecular Tweezers.
Weil T, Groß R, Röcker A, Bravo-Rodriguez K, Heid C, Sowislok A, Le MH, Erwin N, Dwivedi M, Bart SM, Bates P, Wettstein L, Müller JA, Harms M, Sparrer K, Ruiz-Blanco YB, Stürzel CM, von Einem J, Lippold S, Read C, Walther P, Hebel M, Kreppel F, Klärner FG, Bitan G, Ehrmann M, Weil T, Winter R, Schrader T, Shorter J, Sanchez-Garcia E, Münch J. Weil T, et al. J Am Chem Soc. 2020 Oct 7;142(40):17024-17038. doi: 10.1021/jacs.0c06400. Epub 2020 Sep 28. J Am Chem Soc. 2020. PMID: 32926779 Free PMC article.
Drug Inhibition of SARS-CoV-2 Replication in Human Pluripotent Stem Cell-Derived Intestinal Organoids.
Krüger J, Groß R, Conzelmann C, Müller JA, Koepke L, Sparrer KMJ, Weil T, Schütz D, Seufferlein T, Barth TFE, Stenger S, Heller S, Münch J, Kleger A. Krüger J, et al. Among authors: sparrer kmj. Cell Mol Gastroenterol Hepatol. 2021;11(4):935-948. doi: 10.1016/j.jcmgh.2020.11.003. Epub 2020 Nov 10. Cell Mol Gastroenterol Hepatol. 2021. PMID: 33186749 Free PMC article.
68 results