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Resistance to the isocitrate dehydrogenase 1 mutant inhibitor ivosidenib can be overcome by alternative dimer-interface binding inhibitors.
Reinbold R, Hvinden IC, Rabe P, Herold RA, Finch A, Wood J, Morgan M, Staudt M, Clifton IJ, Armstrong FA, McCullagh JSO, Redmond J, Bardella C, Abboud MI, Schofield CJ. Reinbold R, et al. Among authors: schofield cj. Nat Commun. 2022 Aug 15;13(1):4785. doi: 10.1038/s41467-022-32436-4. Nat Commun. 2022. PMID: 35970853 Free PMC article.
NADP(H)-dependent biocatalysis without adding NADP(H).
Herold RA, Reinbold R, Schofield CJ, Armstrong FA. Herold RA, et al. Among authors: schofield cj. Proc Natl Acad Sci U S A. 2023 Jan 3;120(1):e2214123120. doi: 10.1073/pnas.2214123120. Epub 2022 Dec 27. Proc Natl Acad Sci U S A. 2023. PMID: 36574703 Free PMC article.
Human Oxygenase Variants Employing a Single Protein FeII Ligand Are Catalytically Active.
Brasnett A, Pfeffer I, Brewitz L, Chowdhury R, Nakashima Y, Tumber A, McDonough MA, Schofield CJ. Brasnett A, et al. Among authors: schofield cj. Angew Chem Weinheim Bergstr Ger. 2021 Jun 21;133(26):14778-14784. doi: 10.1002/ange.202103711. Epub 2021 May 19. Angew Chem Weinheim Bergstr Ger. 2021. PMID: 38505373 Free PMC article.
Cyclobutanone Mimics of Intermediates in Metallo-β-Lactamase Catalysis.
Abboud MI, Kosmopoulou M, Krismanich AP, Johnson JW, Hinchliffe P, Brem J, Claridge TDW, Spencer J, Schofield CJ, Dmitrienko GI. Abboud MI, et al. Among authors: schofield cj. Chemistry. 2018 Apr 17;24(22):5734-5737. doi: 10.1002/chem.201705886. Epub 2018 Jan 17. Chemistry. 2018. PMID: 29250863 Free PMC article.
711 results