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CD137 and CD137L signals are main drivers of type 1, cell-mediated immune responses.
Dharmadhikari B, Wu M, Abdullah NS, Rajendran S, Ishak ND, Nickles E, Harfuddin Z, Schwarz H. Dharmadhikari B, et al. Among authors: nickles e. Oncoimmunology. 2015 Nov 11;5(4):e1113367. doi: 10.1080/2162402X.2015.1113367. eCollection 2016 Apr. Oncoimmunology. 2015. PMID: 27141396 Free PMC article. Review.
Dendritic cell therapy with CD137L-DC-EBV-VAX in locally recurrent or metastatic nasopharyngeal carcinoma is safe and confers clinical benefit.
Nickles E, Dharmadhikari B, Yating L, Walsh RJ, Koh LP, Poon M, Tan LK, Wang LZ, Ang Y, Asokumaran Y, Chong WQ, Huang Y, Loh KS, Tay J, Soo R, Koh M, Ho LP, Chan M, Niam M, Soh M, Luah YH, Lim CM, Kaliaperumal N, Au VB, Talib NBSN, Sng R, Connolly JE, Goh BC, Schwarz H. Nickles E, et al. Cancer Immunol Immunother. 2022 Jun;71(6):1531-1543. doi: 10.1007/s00262-021-03075-3. Epub 2021 Oct 18. Cancer Immunol Immunother. 2022. PMID: 34661709 Free PMC article. Clinical Trial.
Destroy, what destroys you.
Luu K, Nickles E, Schwarz H. Luu K, et al. Among authors: nickles e. Oncoimmunology. 2019 Nov 3;9(1):1685301. doi: 10.1080/2162402X.2019.1685301. eCollection 2020. Oncoimmunology. 2019. PMID: 32002301 Free PMC article.