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Cannabidiol inhibits the skeletal muscle Nav1.4 by blocking its pore and by altering membrane elasticity.
Ghovanloo MR, Choudhury K, Bandaru TS, Fouda MA, Rayani K, Rusinova R, Phaterpekar T, Nelkenbrecher K, Watkins AR, Poburko D, Thewalt J, Andersen OS, Delemotte L, Goodchild SJ, Ruben PC. Ghovanloo MR, et al. Among authors: ruben pc. J Gen Physiol. 2021 May 3;153(5):e202012701. doi: 10.1085/jgp.202012701. J Gen Physiol. 2021. PMID: 33836525 Free PMC article.
Differential calcium sensitivity in NaV 1.5 mixed syndrome mutants.
Abdelsayed M, Baruteau AE, Gibbs K, Sanatani S, Krahn AD, Probst V, Ruben PC. Abdelsayed M, et al. Among authors: ruben pc. J Physiol. 2017 Sep 15;595(18):6165-6186. doi: 10.1113/JP274536. Epub 2017 Aug 20. J Physiol. 2017. PMID: 28734073 Free PMC article.
Cannabidiol interactions with voltage-gated sodium channels.
Sait LG, Sula A, Ghovanloo MR, Hollingworth D, Ruben PC, Wallace BA. Sait LG, et al. Among authors: ruben pc. Elife. 2020 Oct 22;9:e58593. doi: 10.7554/eLife.58593. Elife. 2020. PMID: 33089780 Free PMC article.
Inhibitory effects of cannabidiol on voltage-dependent sodium currents.
Ghovanloo MR, Shuart NG, Mezeyova J, Dean RA, Ruben PC, Goodchild SJ. Ghovanloo MR, et al. Among authors: ruben pc. J Biol Chem. 2018 Oct 26;293(43):16546-16558. doi: 10.1074/jbc.RA118.004929. Epub 2018 Sep 14. J Biol Chem. 2018. PMID: 30219789 Free PMC article.
89 results