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Orally active beta-lactam inhibitors of human leukocyte elastase. 3. Stereospecific synthesis and structure-activity relationships for 3,3-dialkylazetidin-2-ones.
J Med Chem. 1995 Jun 23;38(13):2449-62. doi: 10.1021/jm00013a021.
J Med Chem. 1995.
PMID: 7608910
Inhibition of human leukocyte elastase. 4. Selection of a substituted cephalosporin (L-658,758) as a topical aerosol.
Finke PE, Shah SK, Ashe BM, Ball RG, Blacklock TJ, Bonney RJ, Brause KA, Chandler GO, Cotton M, Davies P, et al.
Finke PE, et al. Among authors: chandler go.
J Med Chem. 1992 Oct 16;35(21):3731-44. doi: 10.1021/jm00099a002.
J Med Chem. 1992.
PMID: 1433188
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Orally active beta-lactam inhibitors of human leukocyte elastase-1. Activity of 3,3-diethyl-2-azetidinones.
Shah SK, Dorn CP Jr, Finke PE, Hale JJ, Hagmann WK, Brause KA, Chandler GO, Kissinger AL, Ashe BM, Weston H, et al.
Shah SK, et al. Among authors: chandler go.
J Med Chem. 1992 Oct 16;35(21):3745-54. doi: 10.1021/jm00099a003.
J Med Chem. 1992.
PMID: 1433189
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Inhibition of human leukocyte elastase. 1. Inhibition by C-7-substituted cephalosporin tert-butyl esters.
Doherty JB, Ashe BM, Barker PL, Blacklock TJ, Butcher JW, Chandler GO, Dahlgren ME, Davies P, Dorn CP Jr, Finke PE, et al.
Doherty JB, et al. Among authors: chandler go.
J Med Chem. 1990 Sep;33(9):2513-21. doi: 10.1021/jm00171a028.
J Med Chem. 1990.
PMID: 2391691
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Inhibition of human leukocyte elastase. 3. Synthesis and activity of 3'-substituted cephalosporins.
Shah SK, Brause KA, Chandler GO, Finke PE, Ashe BM, Weston H, Knight WB, Maycock AL, Doherty JB.
Shah SK, et al. Among authors: chandler go.
J Med Chem. 1990 Sep;33(9):2529-35. doi: 10.1021/jm00171a030.
J Med Chem. 1990.
PMID: 2391693
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Chemical, biochemical, pharmacokinetic, and biological properties of L-680,833: a potent, orally active monocyclic beta-lactam inhibitor of human polymorphonuclear leukocyte elastase.
Doherty JB, Shah SK, Finke PE, Dorn CP Jr, Hagmann WK, Hale JJ, Kissinger AL, Thompson KR, Brause K, Chandler GO, et al.
Doherty JB, et al. Among authors: chandler go.
Proc Natl Acad Sci U S A. 1993 Sep 15;90(18):8727-31. doi: 10.1073/pnas.90.18.8727.
Proc Natl Acad Sci U S A. 1993.
PMID: 8378355
Free PMC article.
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Cephalosporin antibiotics can be modified to inhibit human leukocyte elastase.
Doherty JB, Ashe BM, Argenbright LW, Barker PL, Bonney RJ, Chandler GO, Dahlgren ME, Dorn CP Jr, Finke PE, Firestone RA, et al.
Doherty JB, et al. Among authors: chandler go.
Nature. 1986 Jul 10-16;322(6075):192-4. doi: 10.1038/322192a0.
Nature. 1986.
PMID: 3636599
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