Nelson SD - Search Results

1

Mechanisms of the formation and disposition of reactive metabolites that can cause acute liver injury.

Nelson SD. Nelson SD. Drug Metab Rev. 1995;27(1-2):147-77. doi: 10.3109/03602539509029821. Drug Metab Rev. 1995. PMID: 7641574 Review.

2

Investigations of mechanisms of reactive metabolite formation from (R)-(+)-pulegone.

Nelson SD, McClanahan RH, Thomassen D, Gordon WP, Knebel N. Nelson SD, et al. Xenobiotica. 1992 Sep-Oct;22(9-10):1157-64. doi: 10.3109/00498259209051869. Xenobiotica. 1992. PMID: 1441606 Review.

3

Metabolism of (R)-(+)-pulegone and (R)-(+)-menthofuran by human liver cytochrome P-450s: evidence for formation of a furan epoxide.

Khojasteh-Bakht SC, Chen W, Koenigs LL, Peter RM, Nelson SD. Khojasteh-Bakht SC, et al. Among authors: nelson sd. Drug Metab Dispos. 1999 May;27(5):574-80. Drug Metab Dispos. 1999. PMID: 10220485

4

Reactive intermediates in the oxidation of menthofuran by cytochromes P-450.

Thomassen D, Knebel N, Slattery JT, McClanahan RH, Nelson SD. Thomassen D, et al. Among authors: nelson sd. Chem Res Toxicol. 1992 Jan-Feb;5(1):123-30. doi: 10.1021/tx00025a021. Chem Res Toxicol. 1992. PMID: 1581528

5

Partial characterization of biliary metabolites of pulegone by tandem mass spectrometry. Detection of glucuronide, glutathione, and glutathionyl glucuronide conjugates.

Thomassen D, Pearson PG, Slattery JT, Nelson SD. Thomassen D, et al. Among authors: nelson sd. Drug Metab Dispos. 1991 Sep-Oct;19(5):997-1003. Drug Metab Dispos. 1991. PMID: 1686249

6

Characterization of glutathione conjugates of reactive metabolites of 3'-hydroxyacetanilide, a nonhepatotoxic positional isomer of acetaminophen.

Rashed MS, Nelson SD. Rashed MS, et al. Among authors: nelson sd. Chem Res Toxicol. 1989 Jan-Feb;2(1):41-5. doi: 10.1021/tx00007a007. Chem Res Toxicol. 1989. PMID: 2519230

7

Metabolic activation of (R)-(+)-pulegone to a reactive enonal that covalently binds to mouse liver proteins.

McClanahan RH, Thomassen D, Slattery JT, Nelson SD. McClanahan RH, et al. Among authors: nelson sd. Chem Res Toxicol. 1989 Sep-Oct;2(5):349-55. doi: 10.1021/tx00011a013. Chem Res Toxicol. 1989. PMID: 2519826

8

Contribution of menthofuran to the hepatotoxicity of pulegone: assessment based on matched area under the curve and on matched time course.

Thomassen D, Slattery JT, Nelson SD. Thomassen D, et al. Among authors: nelson sd. J Pharmacol Exp Ther. 1988 Mar;244(3):825-9. J Pharmacol Exp Ther. 1988. PMID: 3252034

9

Inhibition and activation of acetaminophen reactive metabolite formation by caffeine. Roles of cytochromes P-450IA1 and IIIA2.

Lee CA, Thummel KE, Kalhorn TF, Nelson SD, Slattery JT. Lee CA, et al. Among authors: nelson sd. Drug Metab Dispos. 1991 Mar-Apr;19(2):348-53. Drug Metab Dispos. 1991. PMID: 1676635

10

The metabolism of the abortifacient terpene, (R)-(+)-pulegone, to a proximate toxin, menthofuran.

Gordon WP, Huitric AC, Seth CL, McClanahan RH, Nelson SD. Gordon WP, et al. Among authors: nelson sd. Drug Metab Dispos. 1987 Sep-Oct;15(5):589-94. Drug Metab Dispos. 1987. PMID: 2891472

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