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Crystal structure of tert-butyldimethylsilyl-spiroaminooxathioledioxide-thymine (TSAO-T) in complex with HIV-1 reverse transcriptase (RT) redefines the elastic limits of the non-nucleoside inhibitor-binding pocket.
Das K, Bauman JD, Rim AS, Dharia C, Clark AD Jr, Camarasa MJ, Balzarini J, Arnold E. Das K, et al. Among authors: clark ad jr. J Med Chem. 2011 Apr 28;54(8):2727-37. doi: 10.1021/jm101536x. Epub 2011 Mar 29. J Med Chem. 2011. PMID: 21446702 Free PMC article.
Structural basis of HIV-1 resistance to AZT by excision.
Tu X, Das K, Han Q, Bauman JD, Clark AD Jr, Hou X, Frenkel YV, Gaffney BL, Jones RA, Boyer PL, Hughes SH, Sarafianos SG, Arnold E. Tu X, et al. Among authors: clark ad jr. Nat Struct Mol Biol. 2010 Oct;17(10):1202-9. doi: 10.1038/nsmb.1908. Epub 2010 Sep 19. Nat Struct Mol Biol. 2010. PMID: 20852643 Free PMC article.
Structural basis for the role of the K65R mutation in HIV-1 reverse transcriptase polymerization, excision antagonism, and tenofovir resistance.
Das K, Bandwar RP, White KL, Feng JY, Sarafianos SG, Tuske S, Tu X, Clark AD Jr, Boyer PL, Hou X, Gaffney BL, Jones RA, Miller MD, Hughes SH, Arnold E. Das K, et al. Among authors: clark ad jr. J Biol Chem. 2009 Dec 11;284(50):35092-100. doi: 10.1074/jbc.M109.022525. Epub 2009 Oct 7. J Biol Chem. 2009. PMID: 19812032 Free PMC article.
Crystal engineering of HIV-1 reverse transcriptase for structure-based drug design.
Bauman JD, Das K, Ho WC, Baweja M, Himmel DM, Clark AD Jr, Oren DA, Boyer PL, Hughes SH, Shatkin AJ, Arnold E. Bauman JD, et al. Among authors: clark ad jr. Nucleic Acids Res. 2008 Sep;36(15):5083-92. doi: 10.1093/nar/gkn464. Epub 2008 Aug 1. Nucleic Acids Res. 2008. PMID: 18676450 Free PMC article.
HIV-1 reverse transcriptase structure with RNase H inhibitor dihydroxy benzoyl naphthyl hydrazone bound at a novel site.
Himmel DM, Sarafianos SG, Dharmasena S, Hossain MM, McCoy-Simandle K, Ilina T, Clark AD Jr, Knight JL, Julias JG, Clark PK, Krogh-Jespersen K, Levy RM, Hughes SH, Parniak MA, Arnold E. Himmel DM, et al. Among authors: clark ad jr. ACS Chem Biol. 2006 Dec 20;1(11):702-12. doi: 10.1021/cb600303y. ACS Chem Biol. 2006. PMID: 17184135 Free PMC article.
Crystal structures for HIV-1 reverse transcriptase in complexes with three pyridinone derivatives: a new class of non-nucleoside inhibitors effective against a broad range of drug-resistant strains.
Himmel DM, Das K, Clark AD Jr, Hughes SH, Benjahad A, Oumouch S, Guillemont J, Coupa S, Poncelet A, Csoka I, Meyer C, Andries K, Nguyen CH, Grierson DS, Arnold E. Himmel DM, et al. Among authors: clark ad jr. J Med Chem. 2005 Dec 1;48(24):7582-91. doi: 10.1021/jm0500323. J Med Chem. 2005. PMID: 16302798
Inhibition of bacterial RNA polymerase by streptolydigin: stabilization of a straight-bridge-helix active-center conformation.
Tuske S, Sarafianos SG, Wang X, Hudson B, Sineva E, Mukhopadhyay J, Birktoft JJ, Leroy O, Ismail S, Clark AD Jr, Dharia C, Napoli A, Laptenko O, Lee J, Borukhov S, Ebright RH, Arnold E. Tuske S, et al. Among authors: clark ad jr. Cell. 2005 Aug 26;122(4):541-52. doi: 10.1016/j.cell.2005.07.017. Cell. 2005. PMID: 16122422 Free PMC article.
32 results