Mewshaw RE - Search Results

1

Examination of the D2/5-HT2 affinity ratios of resolved 5,6,7,8,9,10-hexahydro-7,10-iminocyclohept[b]indoles: an enantioselective approach toward the design of potential atypical antipsychotics.

Mewshaw RE, Abreu ME, Silverman LS, Mathew RM, Tiffany CW, Bailey MA, Karbon EW, Ferkany JW, Kaiser C. Mewshaw RE, et al. J Med Chem. 1993 Oct 15;36(21):3073-6. doi: 10.1021/jm00073a005. J Med Chem. 1993. PMID: 7901415

2

Synthesis and in vitro evaluation of 5,6,7,8,9,10-hexahydro-7,10-iminocyclohept[b]indoles: high-affinity ligands for the N,N'-di-o-tolylguanidine-labeled sigma binding site.

Mewshaw RE, Sherrill RG, Mathew RM, Kaiser C, Bailey MA, Karbon EW. Mewshaw RE, et al. J Med Chem. 1993 Feb 5;36(3):343-52. doi: 10.1021/jm00055a005. J Med Chem. 1993. PMID: 8426363

3

Bridged gamma-carbolines and derivatives possessing selective and combined affinity for 5-HT2 and D2 receptors.

Mewshaw RE, Silverman LS, Mathew RM, Kaiser C, Sherrill RG, Cheng M, Tiffany CW, Karbon EW, Bailey MA, Borosky SA, et al. Mewshaw RE, et al. J Med Chem. 1993 May 14;36(10):1488-95. doi: 10.1021/jm00062a023. J Med Chem. 1993. PMID: 8496917

4

New generation dopaminergic agents. 1. Discovery of a novel scaffold which embraces the D2 agonist pharmacophore. Structure-activity relationships of a series of 2-(aminomethyl)chromans.

Mewshaw RE, Kavanagh J, Stack G, Marquis KL, Shi X, Kagan MZ, Webb MB, Katz AH, Park A, Kang YH, Abou-Gharbia M, Scerni R, Wasik T, Cortes-Burgos L, Spangler T, Brennan JA, Piesla M, Mazandarani H, Cockett MI, Ochalski R, Coupet J, Andree TH. Mewshaw RE, et al. J Med Chem. 1997 Dec 19;40(26):4235-56. doi: 10.1021/jm9703653. J Med Chem. 1997. PMID: 9435894

5

Fluorenylalkanoic and benzoic acids as novel inhibitors of cell adhesion processes in leukocytes.

Hamilton GS, Mewshaw RE, Bryant CM, Feng Y, Endemann G, Madden KS, Janczak JE, Perumattam J, Stanton LW, Yang X, et al. Hamilton GS, et al. Among authors: mewshaw re. J Med Chem. 1995 May 12;38(10):1650-6. doi: 10.1021/jm00010a009. J Med Chem. 1995. PMID: 7752189

6

Estrogen receptor beta ligands: design and synthesis of new 2-phenyl-isoindole-1,3-diones.

Ullrich JW, Unwalla RJ, Singhaus RR Jr, Harris HA, Mewshaw RE. Ullrich JW, et al. Among authors: mewshaw re. Bioorg Med Chem Lett. 2007 Jan 1;17(1):118-22. doi: 10.1016/j.bmcl.2006.09.088. Epub 2006 Oct 1. Bioorg Med Chem Lett. 2007. PMID: 17049855

7

New generation dopaminergic agents. 6. Structure-activity relationship studies of a series of 4-(aminoethoxy)indole and 4-(aminoethoxy)indolone derivatives based on the newly discovered 3-hydroxyphenoxyethylamine D2 template.

Mewshaw RE, Webb MB, Marquis KL, McGaughey GB, Shi X, Wasik T, Scerni R, Brennan JA, Andree TH. Mewshaw RE, et al. J Med Chem. 1999 Jun 3;42(11):2007-20. doi: 10.1021/jm990023s. J Med Chem. 1999. PMID: 10354409

8

Application of comparative molecular field analysis to dopamine D2 partial agonists.

McGaughey GB, Mewshaw RE. McGaughey GB, et al. Among authors: mewshaw re. Bioorg Med Chem. 1999 Nov;7(11):2453-6. doi: 10.1016/s0968-0896(99)00201-1. Bioorg Med Chem. 1999. PMID: 10632054

9

Studies toward the discovery of the next generation of antidepressants. 3. Dual 5-HT1A and serotonin transporter affinity within a class of N-aryloxyethylindolylalkylamines.

Mewshaw RE, Zhou D, Zhou P, Shi X, Hornby G, Spangler T, Scerni R, Smith D, Schechter LE, Andree TH. Mewshaw RE, et al. J Med Chem. 2004 Jul 15;47(15):3823-42. doi: 10.1021/jm0304010. J Med Chem. 2004. PMID: 15239661

10

Synthesis and biological evaluation of novel compounds within a class of 3-aminochroman derivatives with dual 5-HT1A receptor and serotonin transporter affinity.

Hatzenbuhler NT, Evrard DA, Harrison BL, Huryn D, Inghrim J, Kraml C, Mattes JF, Mewshaw RE, Zhou D, Hornby G, Lin Q, Smith DL, Sullivan KM, Schechter LE, Beyer CE, Andree TH. Hatzenbuhler NT, et al. Among authors: mewshaw re. J Med Chem. 2006 Jul 27;49(15):4785-9. doi: 10.1021/jm060218h. J Med Chem. 2006. PMID: 16854086

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