Development of a model for the delta opioid receptor pharmacophore. 1. Conformationally restricted Tyr1 replacements in the cyclic delta receptor selective tetrapeptide Tyr-c[D-Cys-Phe-D-Pen]OH (JOM-13).
J Med Chem. 1994 Dec 9;37(25):4371-83. doi: 10.1021/jm00051a015.
J Med Chem. 1994.
PMID: 7996549
All these peptides share a common rigid tripeptide cycle with a single energetically preferred backbone conformation and three different conformers of the D-Cys, D-Pen disulfide bridge, two of which are observed in the solid state and in aqueous solution, as previously determined …
All these peptides share a common rigid tripeptide cycle with a single energetically preferred backbone conformation and three different con …