Sprengeler PA - Search Results

1

Design and synthesis of peptidomimetic inhibitors of HIV-1 protease and renin. Evidence for improved transport.

Smith AB 3rd, Hirschmann R, Pasternak A, Akaishi R, Guzman MC, Jones DR, Keenan TP, Sprengeler PA, Darke PL, Emini EA, et al. Smith AB 3rd, et al. Among authors: sprengeler pa. J Med Chem. 1994 Jan 21;37(2):215-8. doi: 10.1021/jm00028a001. J Med Chem. 1994. PMID: 8295206 No abstract available.

2

Design and synthesis of a tetrahydropyran-based inhibitor of mammalian ribonucleotide reductase.

Smith AB 3rd, Sasho S, Barwis BA, Sprengeler P, Barbosa J, Hirschmann R, Cooperman BS. Smith AB 3rd, et al. Bioorg Med Chem Lett. 1998 Nov 17;8(22):3133-6. doi: 10.1016/s0960-894x(98)00575-7. Bioorg Med Chem Lett. 1998. PMID: 9873690 Free article.

3

Design and synthesis of nonpeptide peptidomimetic inhibitors of renin.

Smith AB 3rd, Akaishi R, Jones DR, Keenan TP, Guzman MC, Holcomb RC, Sprengeler PA, Wood JL, Hirschmann R, Holloway MK. Smith AB 3rd, et al. Among authors: sprengeler pa. Biopolymers. 1995;37(1):29-53. doi: 10.1002/bip.360370106. Biopolymers. 1995. PMID: 7880965

4

Synthesis of potent cyclic hexapeptide NK-1 antagonists. Use of a minilibrary in transforming a peptidal somatostatin receptor ligand into an NK-1 receptor ligand via a polyvalent peptidomimetic.

Hirschmann R, Yao W, Cascieri MA, Strader CD, Maechler L, Cichy-Knight MA, Hynes J Jr, van Rijn RD, Sprengeler PA, Smith AB 3rd. Hirschmann R, et al. Among authors: sprengeler pa. J Med Chem. 1996 Jun 21;39(13):2441-8. doi: 10.1021/jm960281e. J Med Chem. 1996. PMID: 8691440

5

The design and synthesis of 2,5-linked pyrrolinones. A potential non-peptide peptidomimetic scaffold.

Smith AB 3rd, Knight SD, Sprengeler PA, Hirschmann R. Smith AB 3rd, et al. Among authors: sprengeler pa. Bioorg Med Chem. 1996 Jul;4(7):1021-34. doi: 10.1016/0968-0896(96)00094-6. Bioorg Med Chem. 1996. PMID: 8831973 Free article.

6

An orally bioavailable pyrrolinone inhibitor of HIV-1 protease: computational analysis and X-ray crystal structure of the enzyme complex.

Smith AB 3rd, Hirschmann R, Pasternak A, Yao W, Sprengeler PA, Holloway MK, Kuo LC, Chen Z, Darke PL, Schleif WA. Smith AB 3rd, et al. Among authors: sprengeler pa. J Med Chem. 1997 Aug 1;40(16):2440-4. doi: 10.1021/jm970195u. J Med Chem. 1997. PMID: 9258349 No abstract available.

7

Molecular modeling, synthesis, and structures of N-methylated 3,5-linked pyrrolin-4-ones toward the creation of a privileged nonpeptide scaffold.

Smith AB 3rd, Favor DA, Sprengeler PA, Guzman MC, Carroll PJ, Furst GT, Hirschmann R. Smith AB 3rd, et al. Among authors: sprengeler pa. Bioorg Med Chem. 1999 Jan;7(1):9-22. doi: 10.1016/s0968-0896(98)00234-x. Bioorg Med Chem. 1999. PMID: 10199652 Free article.

8

Design, synthesis, and biological evaluation of monopyrrolinone-based HIV-1 protease inhibitors.

Smith AB 3rd, Cantin LD, Pasternak A, Guise-Zawacki L, Yao W, Charnley AK, Barbosa J, Sprengeler PA, Hirschmann R, Munshi S, Olsen DB, Schleif WA, Kuo LC. Smith AB 3rd, et al. Among authors: sprengeler pa. J Med Chem. 2003 May 8;46(10):1831-44. doi: 10.1021/jm0204587. J Med Chem. 2003. PMID: 12723947

9

Design and synthesis of sulfur-free cyclic hexapeptides which contain the RGD sequence and bind to the fibrinogen GP IIb/IIIa receptor. A conformation-based correlation between propensity for imide formation and receptor affinity.

Lender A, Yao W, Sprengeler PA, Spanevello RA, Furst GT, Hirschmann R, Smith AB 3rd. Lender A, et al. Among authors: sprengeler pa. Int J Pept Protein Res. 1993 Dec;42(6):509-17. doi: 10.1111/j.1399-3011.1993.tb00358.x. Int J Pept Protein Res. 1993. PMID: 8307682

10

Modulation of receptor and receptor subtype affinities using diastereomeric and enantiomeric monosaccharide scaffolds as a means to structural and biological diversity. A new route to ether synthesis.

Hirschmann R, Hynes J Jr, Cichy-Knight MA, van Rijn RD, Sprengeler PA, Spoors PG, Shakespeare WC, Pietranico-Cole S, Barbosa J, Liu J, Yao W, Rohrer S, Smith AB 3rd. Hirschmann R, et al. Among authors: sprengeler pa. J Med Chem. 1998 Apr 23;41(9):1382-91. doi: 10.1021/jm9800346. J Med Chem. 1998. PMID: 9554871

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