Thompson AM - Search Results

1

Tyrosine kinase inhibitors. 1. Structure-activity relationships for inhibition of epidermal growth factor receptor tyrosine kinase activity by 2,3-dihydro-2-thioxo-1H-indole-3-alkanoic acids and 2,2'-dithiobis(1H-indole-3-alkanoic acids).

Thompson AM, Rewcastle GW, Tercel M, Dobrusin EM, Fry DW, Kraker AJ, Denny WA. Thompson AM, et al. J Med Chem. 1993 Aug 20;36(17):2459-69. doi: 10.1021/jm00069a003. J Med Chem. 1993. PMID: 8355247

2

Tyrosine kinase inhibitors. 2. Synthesis of 2,2'-dithiobis(1H-indole-3-alkanamides) and investigation of their inhibitory activity against epidermal growth factor receptor and pp60v-src protein tyrosine kinases.

Thompson AM, Fry DW, Kraker AJ, Denny WA. Thompson AM, et al. J Med Chem. 1994 Mar 4;37(5):598-609. doi: 10.1021/jm00031a009. J Med Chem. 1994. PMID: 7510340

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Tyrosine kinase inhibitors. 7. 7-Amino-4-(phenylamino)- and 7-amino-4-[(phenylmethyl)amino]pyrido[4,3-d]pyrimidines: a new class of inhibitors of the tyrosine kinase activity of the epidermal growth factor receptor.

Thompson AM, Bridges AJ, Fry DW, Kraker AJ, Denny WA. Thompson AM, et al. J Med Chem. 1995 Sep 15;38(19):3780-8. doi: 10.1021/jm00019a007. J Med Chem. 1995. PMID: 7562908

4

Tyrosine kinase inhibitors. 4. Structure-activity relationships among N- and 3-substituted 2,2'-dithiobis(1H-indoles) for in vitro inhibition of receptor and nonreceptor protein tyrosine kinases.

Palmer BD, Rewcastle GW, Thompson AM, Boyd M, Showalter HD, Sercel AD, Fry DW, Kraker AJ, Denny WA. Palmer BD, et al. Among authors: thompson am. J Med Chem. 1995 Jan 6;38(1):58-67. doi: 10.1021/jm00001a011. J Med Chem. 1995. PMID: 7837241

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Tyrosine kinase inhibitors. 10. Isomeric 4-[(3-bromophenyl)amino]pyrido[d]-pyrimidines are potent ATP binding site inhibitors of the tyrosine kinase function of the epidermal growth factor receptor.

Rewcastle GW, Palmer BD, Thompson AM, Bridges AJ, Cody DR, Zhou H, Fry DW, McMichael A, Denny WA. Rewcastle GW, et al. Among authors: thompson am. J Med Chem. 1996 Apr 26;39(9):1823-35. doi: 10.1021/jm9508651. J Med Chem. 1996. PMID: 8627606

6

Tyrosine kinase inhibitors. 6. Structure-activity relationships among N- and 3-substituted 2,2'-diselenobis(1H-indoles) for inhibition of protein tyrosine kinases and comparative in vitro and in vivo studies against selected sulfur congeners.

Showalter HD, Sercel AD, Leja BM, Wolfangel CD, Ambroso LA, Elliott WL, Fry DW, Kraker AJ, Howard CT, Lu GH, Moore CW, Nelson JM, Roberts BJ, Vincent PW, Denny WA, Thompson AM. Showalter HD, et al. Among authors: thompson am. J Med Chem. 1997 Feb 14;40(4):413-26. doi: 10.1021/jm960689b. J Med Chem. 1997. PMID: 9046331

7

Tyrosine kinase inhibitors. 13. Structure-activity relationships for soluble 7-substituted 4-[(3-bromophenyl)amino]pyrido[4,3-d]pyrimidines designed as inhibitors of the tyrosine kinase activity of the epidermal growth factor receptor.

Thompson AM, Murray DK, Elliott WL, Fry DW, Nelson JA, Showalter HD, Roberts BJ, Vincent PW, Denny WA. Thompson AM, et al. J Med Chem. 1997 Nov 21;40(24):3915-25. doi: 10.1021/jm970366v. J Med Chem. 1997. PMID: 9397172

8

Synthesis and structure-activity relationships of 7-substituted 3-(2, 6-dichlorophenyl)-1,6-naphthyridin-2(1H)-ones as selective inhibitors of pp60(c-src).

Thompson AM, Rewcastle GW, Boushelle SL, Hartl BG, Kraker AJ, Lu GH, Batley BL, Panek RL, Showalter HD, Denny WA. Thompson AM, et al. J Med Chem. 2000 Aug 10;43(16):3134-47. doi: 10.1021/jm000148t. J Med Chem. 2000. PMID: 10956222

9

3-(3,5-Dimethoxyphenyl)-1,6-naphthyridine-2,7-diamines and related 2-urea derivatives are potent and selective inhibitors of the FGF receptor-1 tyrosine kinase.

Thompson AM, Connolly CJ, Hamby JM, Boushelle S, Hartl BG, Amar AM, Kraker AJ, Driscoll DL, Steinkampf RW, Patmore SJ, Vincent PW, Roberts BJ, Elliott WL, Klohs W, Leopold WR, Showalter HD, Denny WA. Thompson AM, et al. J Med Chem. 2000 Nov 2;43(22):4200-11. doi: 10.1021/jm000161d. J Med Chem. 2000. PMID: 11063616

10

Synthesis and structure-activity relationships of soluble 7-substituted 3-(3,5-dimethoxyphenyl)-1,6-naphthyridin-2-amines and related ureas as dual inhibitors of the fibroblast growth factor receptor-1 and vascular endothelial growth factor receptor-2 tyrosine kinases.

Thompson AM, Delaney AM, Hamby JM, Schroeder MC, Spoon TA, Crean SM, Showalter HD, Denny WA. Thompson AM, et al. J Med Chem. 2005 Jul 14;48(14):4628-53. doi: 10.1021/jm0500931. J Med Chem. 2005. PMID: 16000000

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