Welsh KM - Search Results

1

Design of thymidylate synthase inhibitors using protein crystal structures: the synthesis and biological evaluation of a novel class of 5-substituted quinazolinones.

Webber SE, Bleckman TM, Attard J, Deal JG, Kathardekar V, Welsh KM, Webber S, Janson CA, Matthews DA, Smith WW, et al. Webber SE, et al. Among authors: welsh km. J Med Chem. 1993 Mar 19;36(6):733-46. doi: 10.1021/jm00058a010. J Med Chem. 1993. PMID: 8459400

2

Stereochemical mechanism of action for thymidylate synthase based on the X-ray structure of the covalent inhibitory ternary complex with 5-fluoro-2'-deoxyuridylate and 5,10-methylenetetrahydrofolate.

Matthews DA, Villafranca JE, Janson CA, Smith WW, Welsh K, Freer S. Matthews DA, et al. J Mol Biol. 1990 Aug 20;214(4):937-48. doi: 10.1016/0022-2836(90)90347-O. J Mol Biol. 1990. PMID: 2201779

3

Crystal-structure-based design and synthesis of benz[cd]indole-containing inhibitors of thymidylate synthase.

Varney MD, Marzoni GP, Palmer CL, Deal JG, Webber S, Welsh KM, Bacquet RJ, Bartlett CA, Morse CA, Booth CL, et al. Varney MD, et al. Among authors: welsh km. J Med Chem. 1992 Feb 21;35(4):663-76. doi: 10.1021/jm00082a006. J Med Chem. 1992. PMID: 1542093

4

Design and synthesis of novel 6,7-imidazotetrahydroquinoline inhibitors of thymidylate synthase using iterative protein crystal structure analysis.

Reich SH, Fuhry MA, Nguyen D, Pino MJ, Welsh KM, Webber S, Janson CA, Jordan SR, Matthews DA, Smith WW, et al. Reich SH, et al. Among authors: welsh km. J Med Chem. 1992 Mar 6;35(5):847-58. doi: 10.1021/jm00083a007. J Med Chem. 1992. PMID: 1548676

5

Synthesis and biological evaluation of novel 2,6-diaminobenz[cd]indole inhibitors of thymidylate synthase using the protein structure as a guide.

Varney MD, Palmer CL, Deal JG, Webber S, Welsh KM, Bartlett CA, Morse CA, Smith WW, Janson CA. Varney MD, et al. Among authors: welsh km. J Med Chem. 1995 May 26;38(11):1892-903. doi: 10.1021/jm00011a009. J Med Chem. 1995. PMID: 7783121

6

Structure-based design of lipophilic quinazoline inhibitors of thymidylate synthase.

Jones TR, Varney MD, Webber SE, Lewis KK, Marzoni GP, Palmer CL, Kathardekar V, Welsh KM, Webber S, Matthews DA, Appelt K, Smith WW, Janson CA, Villafranca JE, Bacquet RJ, Howland EF, Booth CL, Herrmann SM, Ward RW, White J, Moomaw EW, Bartlett CA, Morse CA. Jones TR, et al. Among authors: welsh km. J Med Chem. 1996 Feb 16;39(4):904-17. doi: 10.1021/jm9502652. J Med Chem. 1996. PMID: 8632414

7

Structure-based design of substituted diphenyl sulfones and sulfoxides as lipophilic inhibitors of thymidylate synthase.

Jones TR, Webber SE, Varney MD, Reddy MR, Lewis KK, Kathardekar V, Mazdiyasni H, Deal J, Nguyen D, Welsh KM, Webber S, Johnston A, Matthews DA, Smith WW, Janson CA, Bacquet RJ, Howland EF, Booth CL, Herrmann SM, Ward RW, White J, Bartlett CA, Morse CA. Jones TR, et al. Among authors: welsh km. J Med Chem. 1997 Feb 28;40(5):677-83. doi: 10.1021/jm960613f. J Med Chem. 1997. PMID: 9057854

8

Structure of and kinetic channelling in bifunctional dihydrofolate reductase-thymidylate synthase.

Knighton DR, Kan CC, Howland E, Janson CA, Hostomska Z, Welsh KM, Matthews DA. Knighton DR, et al. Among authors: welsh km. Nat Struct Biol. 1994 Mar;1(3):186-94. doi: 10.1038/nsb0394-186. Nat Struct Biol. 1994. PMID: 7656037

9

Fragment-based design of small molecule X-linked inhibitor of apoptosis protein inhibitors.

Huang JW, Zhang Z, Wu B, Cellitti JF, Zhang X, Dahl R, Shiau CW, Welsh K, Emdadi A, Stebbins JL, Reed JC, Pellecchia M. Huang JW, et al. J Med Chem. 2008 Nov 27;51(22):7111-8. doi: 10.1021/jm8006992. J Med Chem. 2008. PMID: 18956862 Free PMC article.

10

Design, synthesis and evaluation of inhibitor of apoptosis protein (IAP) antagonists that are highly selective for the BIR2 domain of XIAP.

Ardecky RJ, Welsh K, Finlay D, Lee PS, González-López M, Ganji SR, Ravanan P, Mace PD, Riedl SJ, Vuori K, Reed JC, Cosford ND. Ardecky RJ, et al. Bioorg Med Chem Lett. 2013 Jul 15;23(14):4253-7. doi: 10.1016/j.bmcl.2013.04.096. Epub 2013 May 14. Bioorg Med Chem Lett. 2013. PMID: 23743278 Free PMC article.

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