Pritchard MC - Search Results

1

Use of a dipeptide chemical library in the development of non-peptide tachykinin NK3 receptor selective antagonists.

Boden P, Eden JM, Hodgson J, Horwell DC, Hughes J, McKnight AT, Lewthwaite RA, Pritchard MC, Raphy J, Meecham K, Ratcliffe GS, Suman-Chauhan N, Woodruff GN. Boden P, et al. Among authors: pritchard mc. J Med Chem. 1996 Apr 12;39(8):1664-75. doi: 10.1021/jm950892r. J Med Chem. 1996. PMID: 8648606

2

'Targeted' molecular diversity: design and development of non-peptide antagonists for cholecystokinin and tachykinin receptors.

Horwell D, Pritchard M, Raphy J, Ratcliffe G. Horwell D, et al. Immunopharmacology. 1996 Jun;33(1-3):68-72. doi: 10.1016/0162-3109(96)00058-6. Immunopharmacology. 1996. PMID: 8856117 Review.

3

Rationally designed "dipeptoid" analogues of CCK. Acid mimics of the potent and selective non-peptide CCK-B receptor antagonist CI-988.

Drysdale MJ, Pritchard MC, Horwell DC. Drysdale MJ, et al. Among authors: pritchard mc. J Med Chem. 1992 Jul 10;35(14):2573-81. doi: 10.1021/jm00092a007. J Med Chem. 1992. PMID: 1635058

4

Rationally designed "dipeptoid" analogues of CCK. alpha-Methyltryptophan derivatives as highly selective and orally active gastrin and CCK-B antagonists with potent anxiolytic properties.

Horwell DC, Hughes J, Hunter JC, Pritchard MC, Richardson RS, Roberts E, Woodruff GN. Horwell DC, et al. Among authors: pritchard mc. J Med Chem. 1991 Jan;34(1):404-14. doi: 10.1021/jm00105a062. J Med Chem. 1991. PMID: 1671419

5

Rational design of high affinity tachykinin NK2 receptor antagonists.

Boyle S, Guard S, Hodgson J, Horwell DC, Howson W, Hughes J, McKnight A, Martin K, Pritchard MC, Watling KJ, et al. Boyle S, et al. Among authors: pritchard mc. Bioorg Med Chem. 1994 Feb;2(2):101-13. doi: 10.1016/s0968-0896(00)82006-4. Bioorg Med Chem. 1994. PMID: 7922121

6

Rational design of high affinity tachykinin NK1 receptor antagonists.

Boyle S, Guard S, Higginbottom M, Horwell DC, Howson W, McKnight AT, Martin K, Pritchard MC, O'Toole J, Raphy J, et al. Boyle S, et al. Among authors: pritchard mc. Bioorg Med Chem. 1994 May;2(5):357-70. doi: 10.1016/s0968-0896(00)82192-6. Bioorg Med Chem. 1994. PMID: 7922147

7

[3H]PD 140376: a novel and highly selective antagonist radioligand for the cholecystokininB/gastrin receptor in guinea pig cerebral cortex and gastric mucosa.

Hunter JC, Suman-Chauhan N, Meecham KG, Dissanayake VU, Hill DR, Pritchard MC, Kneen CO, Horwell DC, Hughes J, Woodruff GN. Hunter JC, et al. Among authors: pritchard mc. Mol Pharmacol. 1993 Apr;43(4):595-602. Mol Pharmacol. 1993. PMID: 8474432

8

Cholecystokinin B antagonists. Synthesis and quantitative structure-activity relationships of a series of C-terminal analogues of CI-988.

Augelli-Szafran CE, Horwell DC, Kneen C, Ortwine DF, Pritchard MC, Purchase TS, Roth BD, Trivedi BK, Hill D, Suman-Chauhan N, Webdale L. Augelli-Szafran CE, et al. Among authors: pritchard mc. Bioorg Med Chem. 1996 Oct;4(10):1733-45. doi: 10.1016/0968-0896(96)00185-x. Bioorg Med Chem. 1996. PMID: 8931944

9

Second generation "peptoid" CCK-B receptor antagonists: identification and development of N-(adamantyloxycarbonyl)-alpha-methyl-(R)-tryptophan derivative (CI-1015) with an improved pharmacokinetic profile.

Trivedi BK, Padia JK, Holmes A, Rose S, Wright DS, Hinton JP, Pritchard MC, Eden JM, Kneen C, Webdale L, Suman-Chauhan N, Boden P, Singh L, Field MJ, Hill D. Trivedi BK, et al. Among authors: pritchard mc. J Med Chem. 1998 Jan 1;41(1):38-45. doi: 10.1021/jm970065l. J Med Chem. 1998. PMID: 9438020

10

PD 176252--the first high affinity non-peptide gastrin-releasing peptide (BB2) receptor antagonist.

Ashwood V, Brownhill V, Higginbottom M, Horwell DC, Hughes J, Lewthwaite RA, McKnight AT, Pinnock RD, Pritchard MC, Suman-Chauhan N, Webb C, Williams SC. Ashwood V, et al. Among authors: pritchard mc. Bioorg Med Chem Lett. 1998 Sep 22;8(18):2589-94. doi: 10.1016/s0960-894x(98)00462-4. Bioorg Med Chem Lett. 1998. PMID: 9873586

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