Smith G - Search Results

1

Active-site topologies of human CYP2D6 and its aspartate-301 --> glutamate, asparagine, and glycine mutants.

Mackman R, Tschirret-Guth RA, Smith G, Hayhurst GP, Ellis SW, Lennard MS, Tucker GT, Wolf CR, Ortiz de Montellano PR. Mackman R, et al. Among authors: smith g. Arch Biochem Biophys. 1996 Jul 1;331(1):134-40. doi: 10.1006/abbi.1996.0291. Arch Biochem Biophys. 1996. PMID: 8660692

2

Cytochrome P450 CYP2D6.

Wolf CR, Smith G. Wolf CR, et al. Among authors: smith g. IARC Sci Publ. 1999;(148):209-29. IARC Sci Publ. 1999. PMID: 10493260 Review.

3

Evidence that aspartic acid 301 is a critical substrate-contact residue in the active site of cytochrome P450 2D6.

Ellis SW, Hayhurst GP, Smith G, Lightfoot T, Wong MM, Simula AP, Ackland MJ, Sternberg MJ, Lennard MS, Tucker GT, et al. Ellis SW, et al. Among authors: smith g. J Biol Chem. 1995 Dec 8;270(49):29055-8. doi: 10.1074/jbc.270.49.29055. J Biol Chem. 1995. PMID: 7493924 Free article.

4

Evidence that serine 304 is not a key ligand-binding residue in the active site of cytochrome P450 2D6.

Ellis SW, Hayhurst GP, Lightfoot T, Smith G, Harlow J, Rowland-Yeo K, Larsson C, Mahling J, Lim CK, Wolf CR, Blackburn MG, Lennard MS, Tucker GT. Ellis SW, et al. Among authors: smith g. Biochem J. 2000 Feb 1;345 Pt 3(Pt 3):565-71. Biochem J. 2000. PMID: 10642515 Free PMC article.

5

Observation of structural variation and spin state conversion of cytochrome P450 CYP2B4 on binding of sterically different substrates.

Macdonald ID, Smith GC, Wolf CR, Smith WE. Macdonald ID, et al. Among authors: smith gc, smith we. Biochem Biophys Res Commun. 1996 Sep 4;226(1):51-8. doi: 10.1006/bbrc.1996.1310. Biochem Biophys Res Commun. 1996. PMID: 8806591

6

Pharmacogenetics.

Wolf CR, Smith G. Wolf CR, et al. Among authors: smith g. Br Med Bull. 1999;55(2):366-86. doi: 10.1258/0007142991902439. Br Med Bull. 1999. PMID: 10723863 Review.

7

Production of cytochrome P450 reductase yeast-rat hybrid proteins in Saccharomyces cerevisiae.

Bligh HF, Wolf CR, Smith G, Beggs JD. Bligh HF, et al. Among authors: smith g. Gene. 1992 Jan 2;110(1):33-9. doi: 10.1016/0378-1119(92)90441-q. Gene. 1992. PMID: 1544575

8

Dissection of NADPH-cytochrome P450 oxidoreductase into distinct functional domains.

Smith GC, Tew DG, Wolf CR. Smith GC, et al. Proc Natl Acad Sci U S A. 1994 Aug 30;91(18):8710-4. doi: 10.1073/pnas.91.18.8710. Proc Natl Acad Sci U S A. 1994. PMID: 8078947 Free PMC article.

9

Coexpression of a human P450 (CYP3A4) and P450 reductase generates a highly functional monooxygenase system in Escherichia coli.

Blake JA, Pritchard M, Ding S, Smith GC, Burchell B, Wolf CR, Friedberg T. Blake JA, et al. Among authors: smith gc. FEBS Lett. 1996 Nov 18;397(2-3):210-4. doi: 10.1016/s0014-5793(96)01196-9. FEBS Lett. 1996. PMID: 8955349 Free article.

10

Genetic polymorphisms in xenobiotic metabolism.

Smith CA, Smith G, Wolf CR. Smith CA, et al. Among authors: smith g. Eur J Cancer. 1994;30A(13):1921-35. doi: 10.1016/0959-8049(94)00382-f. Eur J Cancer. 1994. PMID: 7734203 Review. No abstract available.

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