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Transposon mutagenesis of Mb0100 at the ppe1-nrp locus in Mycobacterium bovis disrupts phthiocerol dimycocerosate (PDIM) and glycosylphenol-PDIM biosynthesis, producing an avirulent strain with vaccine properties at least equal to those of M. bovis BCG.
Hotter GS, Wards BJ, Mouat P, Besra GS, Gomes J, Singh M, Bassett S, Kawakami P, Wheeler PR, de Lisle GW, Collins DM. Hotter GS, et al. Among authors: wards bj. J Bacteriol. 2005 Apr;187(7):2267-77. doi: 10.1128/JB.187.7.2267-2277.2005. J Bacteriol. 2005. PMID: 15774869 Free PMC article.
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