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Page 1
Allele-specific control of rodent and human lncRNA KMT2E-AS1 promotes hypoxic endothelial pathology in pulmonary hypertension.
Tai YY, Yu Q, Tang Y, Sun W, Kelly NJ, Okawa S, Zhao J, Schwantes-An TH, Lacoux C, Torrino S, Al Aaraj Y, El Khoury W, Negi V, Liu M, Corey CG, Belmonte F, Vargas SO, Schwartz B, Bhat B, Chau BN, Karnes JH, Satoh T, Barndt RJ, Wu H, Parikh VN, Wang J, Zhang Y, McNamara D, Li G, Speyer G, Wang B, Shiva S, Kaufman B, Kim S, Gomez D, Mari B, Cho MH, Boueiz A, Pauciulo MW, Southgate L, Trembath RC, Sitbon O, Humbert M, Graf S, Morrell NW, Rhodes CJ, Wilkins MR, Nouraie M, Nichols WC, Desai AA, Bertero T, Chan SY. Tai YY, et al. Among authors: chau bn. Sci Transl Med. 2024 Jan 10;16(729):eadd2029. doi: 10.1126/scitranslmed.add2029. Epub 2024 Jan 10. Sci Transl Med. 2024. PMID: 38198571 Free PMC article.
Novel AAV-mediated genome editing therapy improves health and survival in a mouse model of methylmalonic acidemia.
Zhang S, Bastille A, Gordo S, Ramesh N, Vora J, McCarthy E, Zhang X, Frank D, Ko CW, Wu C, Walsh N, Amarwani S, Liao J, Xiong Q, Drouin L, Hebben M, Chiang K, Chau BN. Zhang S, et al. Among authors: chau bn. PLoS One. 2022 Sep 20;17(9):e0274774. doi: 10.1371/journal.pone.0274774. eCollection 2022. PLoS One. 2022. PMID: 36126056 Free PMC article.
Systems-level regulation of microRNA networks by miR-130/301 promotes pulmonary hypertension.
Bertero T, Lu Y, Annis S, Hale A, Bhat B, Saggar R, Saggar R, Wallace WD, Ross DJ, Vargas SO, Graham BB, Kumar R, Black SM, Fratz S, Fineman JR, West JD, Haley KJ, Waxman AB, Chau BN, Cottrill KA, Chan SY. Bertero T, et al. Among authors: chau bn. J Clin Invest. 2022 May 16;132(10):e161077. doi: 10.1172/JCI161077. J Clin Invest. 2022. PMID: 35575096 Free PMC article. No abstract available.
Gene activation of SMN by selective disruption of lncRNA-mediated recruitment of PRC2 for the treatment of spinal muscular atrophy.
Woo CJ, Maier VK, Davey R, Brennan J, Li G, Brothers J 2nd, Schwartz B, Gordo S, Kasper A, Okamoto TR, Johansson HE, Mandefro B, Sareen D, Bialek P, Chau BN, Bhat B, Bullough D, Barsoum J. Woo CJ, et al. Among authors: chau bn. Proc Natl Acad Sci U S A. 2017 Feb 21;114(8):E1509-E1518. doi: 10.1073/pnas.1616521114. Epub 2017 Feb 13. Proc Natl Acad Sci U S A. 2017. PMID: 28193854 Free PMC article.
Matrix Remodeling Promotes Pulmonary Hypertension through Feedback Mechanoactivation of the YAP/TAZ-miR-130/301 Circuit.
Bertero T, Cottrill KA, Lu Y, Haeger CM, Dieffenbach P, Annis S, Hale A, Bhat B, Kaimal V, Zhang YY, Graham BB, Kumar R, Saggar R, Saggar R, Wallace WD, Ross DJ, Black SM, Fratz S, Fineman JR, Vargas SO, Haley KJ, Waxman AB, Chau BN, Fredenburgh LE, Chan SY. Bertero T, et al. Among authors: chau bn. Cell Rep. 2015 Nov 3;13(5):1016-32. doi: 10.1016/j.celrep.2015.09.049. Epub 2015 Oct 22. Cell Rep. 2015. PMID: 26565914 Free PMC article.
Genetic and hypoxic alterations of the microRNA-210-ISCU1/2 axis promote iron-sulfur deficiency and pulmonary hypertension.
White K, Lu Y, Annis S, Hale AE, Chau BN, Dahlman JE, Hemann C, Opotowsky AR, Vargas SO, Rosas I, Perrella MA, Osorio JC, Haley KJ, Graham BB, Kumar R, Saggar R, Saggar R, Wallace WD, Ross DJ, Khan OF, Bader A, Gochuico BR, Matar M, Polach K, Johannessen NM, Prosser HM, Anderson DG, Langer R, Zweier JL, Bindoff LA, Systrom D, Waxman AB, Jin RC, Chan SY. White K, et al. Among authors: chau bn. EMBO Mol Med. 2015 Jun;7(6):695-713. doi: 10.15252/emmm.201404511. EMBO Mol Med. 2015. PMID: 25825391 Free PMC article.
The microRNA-130/301 family controls vasoconstriction in pulmonary hypertension.
Bertero T, Cottrill K, Krauszman A, Lu Y, Annis S, Hale A, Bhat B, Waxman AB, Chau BN, Kuebler WM, Chan SY. Bertero T, et al. Among authors: chau bn. J Biol Chem. 2015 Jan 23;290(4):2069-85. doi: 10.1074/jbc.M114.617845. Epub 2014 Dec 12. J Biol Chem. 2015. PMID: 25505270 Free PMC article.
Anti-microRNA-21 oligonucleotides prevent Alport nephropathy progression by stimulating metabolic pathways.
Gomez IG, MacKenna DA, Johnson BG, Kaimal V, Roach AM, Ren S, Nakagawa N, Xin C, Newitt R, Pandya S, Xia TH, Liu X, Borza DB, Grafals M, Shankland SJ, Himmelfarb J, Portilla D, Liu S, Chau BN, Duffield JS. Gomez IG, et al. Among authors: chau bn. J Clin Invest. 2015 Jan;125(1):141-56. doi: 10.1172/JCI75852. Epub 2014 Nov 21. J Clin Invest. 2015. PMID: 25415439 Free PMC article.
35 results