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Scanning alanine mutagenesis and de-peptidization of a Candida albicans myristoyl-CoA:protein N-myristoyltransferase octapeptide substrate reveals three elements critical for molecular recognition.
McWherter CA, Rocque WJ, Zupec ME, Freeman SK, Brown DL, Devadas B, Getman DP, Sikorski JA, Gordon JI. McWherter CA, et al. Among authors: freeman sk. J Biol Chem. 1997 May 2;272(18):11874-80. doi: 10.1074/jbc.272.18.11874. J Biol Chem. 1997. PMID: 9115247 Free article.
N-myristoylation of Arf proteins in Candida albicans: an in vivo assay for evaluating antifungal inhibitors of myristoyl-CoA: protein N-myristoyltransferase.
Lodge JK, Jackson-Machelski E, Devadas B, Zupec ME, Getman DP, Kishore N, Freeman SK, McWherter CA, Sikorski JA, Gordon JI. Lodge JK, et al. Among authors: freeman sk. Microbiology (Reading). 1997 Feb;143 ( Pt 2):357-366. doi: 10.1099/00221287-143-2-357. Microbiology (Reading). 1997. PMID: 9043113 Free article.
Conformationally constrained [p-(omega-aminoalkyl)phenacetyl]-L-seryl-L-lysyl dipeptide amides as potent peptidomimetic inhibitors of Candida albicans and human myristoyl-CoA:protein N-myristoyl transferase.
Nagarajan SR, Devadas B, Zupec ME, Freeman SK, Brown DL, Lu HF, Mehta PP, Kishore NS, McWherter CA, Getman DP, Gordon JI, Sikorski JA. Nagarajan SR, et al. Among authors: freeman sk. J Med Chem. 1997 May 9;40(10):1422-38. doi: 10.1021/jm9608671. J Med Chem. 1997. PMID: 9154965
Selective peptidic and peptidomimetic inhibitors of Candida albicans myristoylCoA: protein N-myristoyltransferase: a new approach to antifungal therapy.
Sikorski JA, Devadas B, Zupec ME, Freeman SK, Brown DL, Lu HF, Nagarajan S, Mehta PP, Wade AC, Kishore NS, Bryant ML, Getman DP, McWherter CA, Gordon JI. Sikorski JA, et al. Among authors: freeman sk. Biopolymers. 1997;43(1):43-71. doi: 10.1002/(SICI)1097-0282(1997)43:1<43::AID-BIP5>3.0.CO;2-0. Biopolymers. 1997. PMID: 9174411 Review.
Design and synthesis of novel imidazole-substituted dipeptide amides as potent and selective inhibitors of Candida albicans myristoylCoA:protein N-myristoyltransferase and identification of related tripeptide inhibitors with mechanism-based antifungal activity.
Devadas B, Freeman SK, Zupec ME, Lu HF, Nagarajan SR, Kishore NS, Lodge JK, Kuneman DW, McWherter CA, Vinjamoori DV, Getman DP, Gordon JI, Sikorski JA. Devadas B, et al. Among authors: freeman sk. J Med Chem. 1997 Aug 1;40(16):2609-25. doi: 10.1021/jm970094w. J Med Chem. 1997. PMID: 9258368
R-isomers of Arg-Gly-Asp (RGD) mimics as potent alphavbeta3 inhibitors.
Nagarajan SR, Devadas B, Malecha JW, Lu HF, Ruminski PG, Rico JG, Rogers TE, Marrufo LD, Collins JT, Kleine HP, Lantz MK, Zhu J, Green NF, Russell MA, Landis BH, Miller LM, Meyer DM, Duffin TD, Engleman VW, Finn MB, Freeman SK, Griggs DW, Williams ML, Nickols MA, Pegg JA, Shannon KE, Steininger C, Westlin MM, Nickols GA, Keene JL. Nagarajan SR, et al. Among authors: freeman sk. Bioorg Med Chem. 2007 Jun 1;15(11):3783-800. doi: 10.1016/j.bmc.2007.03.034. Epub 2007 Mar 15. Bioorg Med Chem. 2007. PMID: 17399986
Discovery of +(2-{4-[2-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)ethoxy]phenyl}-cyclopropyl)acetic acid as potent and selective alphavbeta3 inhibitor: design, synthesis, and optimization.
Nagarajan SR, Lu HF, Gasiecki AF, Khanna IK, Parikh MD, Desai BN, Rogers TE, Clare M, Chen BB, Russell MA, Keene JL, Duffin T, Engleman VW, Finn MB, Freeman SK, Klover JA, Nickols GA, Nickols MA, Shannon KE, Steininger CA, Westlin WF, Westlin MM, Williams ML. Nagarajan SR, et al. Among authors: freeman sk. Bioorg Med Chem. 2007 May 15;15(10):3390-412. doi: 10.1016/j.bmc.2007.03.020. Epub 2007 Mar 13. Bioorg Med Chem. 2007. PMID: 17387018
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