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Scanning alanine mutagenesis and de-peptidization of a Candida albicans myristoyl-CoA:protein N-myristoyltransferase octapeptide substrate reveals three elements critical for molecular recognition.
McWherter CA, Rocque WJ, Zupec ME, Freeman SK, Brown DL, Devadas B, Getman DP, Sikorski JA, Gordon JI. McWherter CA, et al. Among authors: sikorski ja. J Biol Chem. 1997 May 2;272(18):11874-80. doi: 10.1074/jbc.272.18.11874. J Biol Chem. 1997. PMID: 9115247 Free article.
N-myristoylation of Arf proteins in Candida albicans: an in vivo assay for evaluating antifungal inhibitors of myristoyl-CoA: protein N-myristoyltransferase.
Lodge JK, Jackson-Machelski E, Devadas B, Zupec ME, Getman DP, Kishore N, Freeman SK, McWherter CA, Sikorski JA, Gordon JI. Lodge JK, et al. Among authors: sikorski ja. Microbiology (Reading). 1997 Feb;143 ( Pt 2):357-366. doi: 10.1099/00221287-143-2-357. Microbiology (Reading). 1997. PMID: 9043113 Free article.
Conformationally constrained [p-(omega-aminoalkyl)phenacetyl]-L-seryl-L-lysyl dipeptide amides as potent peptidomimetic inhibitors of Candida albicans and human myristoyl-CoA:protein N-myristoyl transferase.
Nagarajan SR, Devadas B, Zupec ME, Freeman SK, Brown DL, Lu HF, Mehta PP, Kishore NS, McWherter CA, Getman DP, Gordon JI, Sikorski JA. Nagarajan SR, et al. Among authors: sikorski ja. J Med Chem. 1997 May 9;40(10):1422-38. doi: 10.1021/jm9608671. J Med Chem. 1997. PMID: 9154965
Selective peptidic and peptidomimetic inhibitors of Candida albicans myristoylCoA: protein N-myristoyltransferase: a new approach to antifungal therapy.
Sikorski JA, Devadas B, Zupec ME, Freeman SK, Brown DL, Lu HF, Nagarajan S, Mehta PP, Wade AC, Kishore NS, Bryant ML, Getman DP, McWherter CA, Gordon JI. Sikorski JA, et al. Biopolymers. 1997;43(1):43-71. doi: 10.1002/(SICI)1097-0282(1997)43:1<43::AID-BIP5>3.0.CO;2-0. Biopolymers. 1997. PMID: 9174411 Review.
Design and synthesis of novel imidazole-substituted dipeptide amides as potent and selective inhibitors of Candida albicans myristoylCoA:protein N-myristoyltransferase and identification of related tripeptide inhibitors with mechanism-based antifungal activity.
Devadas B, Freeman SK, Zupec ME, Lu HF, Nagarajan SR, Kishore NS, Lodge JK, Kuneman DW, McWherter CA, Vinjamoori DV, Getman DP, Gordon JI, Sikorski JA. Devadas B, et al. Among authors: sikorski ja. J Med Chem. 1997 Aug 1;40(16):2609-25. doi: 10.1021/jm970094w. J Med Chem. 1997. PMID: 9258368
Discovery of novel benzothiazolesulfonamides as potent inhibitors of HIV-1 protease.
Nagarajan SR, De Crescenzo GA, Getman DP, Lu HF, Sikorski JA, Walker JL, McDonald JJ, Houseman KA, Kocan GP, Kishore N, Mehta PP, Funkes-Shippy CL, Blystone L. Nagarajan SR, et al. Among authors: sikorski ja. Bioorg Med Chem. 2003 Nov 3;11(22):4769-77. doi: 10.1016/j.bmc.2003.07.001. Bioorg Med Chem. 2003. PMID: 14556792
46 results